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Remarkably, scientific reports regarding salivary glands sphingolipid metabolism in diabetes are virtually non\u2010existent. This is odd given the well\u2010established link between the both in other tissues (e.g., skeletal muscles, liver) and the key role of these glands in oral health preservation. The aim of this paper is to examine sphingolipids metabolism in the salivary glands in (pre)diabetes (evoked by high fat diet feeding or streptozotocin). Wistar rats were allocated into three groups: control, HFD\u2010, or STZ\u2010diabetes. The content of major sphingolipid classes in the parotid (PSG) and submandibular (SMSG) glands was assessed via chromatography. Additionally, Western blot analyses were employed for the evaluation of key sphingolipid signaling pathway enzyme levels. No changes in ceramide content in the PSG were found, whereas an increase in ceramide concentration for SMSG of the STZ group was observed. This was accompanied by an elevation in SPT1 level. Probably also sphingomyelin hydrolysis was increased in the SMSG of the STZ\u2010diabetic rats, since we observed a significant drop in the amount of SM. PSG and SMSG respond differently to (pre)diabetes, with clearer pattern presented by the later gland. An activation of sphingomyelin signaling pathway was observed in the course of STZ\u2010diabetes, that is, metabolic condition with rapid onset\/progression. Whereas, chronic HFD lead to an inhibition of sphingomyelin signaling pathway in the salivary glands (manifested in an inhibition of ceramide de novo synthesis and accumulation of S1P).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.25939","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T00:14:03Z","timestamp":1490919243000},"page":"2766-2775","source":"Crossref","is-referenced-by-count":11,"title":["Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes"],"prefix":"10.1002","volume":"232","author":[{"given":"Marta","family":"Garbowska","sequence":"first","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomics Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4954-3431","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"\u0141ukaszuk","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Mik\u0142osz","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Wr\u00f3blewski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Kurek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Internal Medicine Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyna","family":"Ostrowska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Chabowski","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"\u017bendzian\u2010Piotrowska","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Ergonomics Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zalewska","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry Medical University of Bialystok  Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070270105"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1238322"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/o59-099"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiologyonline.2007.22.1.15"},{"issue":"4","key":"e_1_2_7_6_1","first-page":"E309","article-title":"Structural and functional salivary disorders in type 2 diabetic patients","volume":"11","author":"Carda C.","year":"2006","journal-title":"Medicina Oral, Patologia Oral y Cirugia Bucal"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12022"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2016.10.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M010595"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(03)00059-3"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"429","article-title":"Effects of streptozotocin\u2010induced diabetes on the rat parotid gland","volume":"51","author":"Hand A. 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