{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:41:44Z","timestamp":1787784104947,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373662"],"award-info":[{"award-number":["81373662"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec><jats:label\/><jats:p>Osteoarthritis (OA) is a common chronic degenerative disease that affects all joints. At present, the pathological processes and mechanisms of OA are still unclear. Innate immunity, a key player in damage to the structure of the joint and the mechanism by which the host attempts to repair OA, affects all pathological stages of the disease. In the present study, our aim was to assess changes in innate immunity during the pathological processes of OA in articular cartilage (AC) and the synovial membrane (SM), which are the major structures in joints, and to systematically examine the histological changes in AC and SM in mild, moderate and severe cases of OA, in order to further speculate about the manner in which the interactions of AC and SM are facilitated by innate immunity. Histological methods (including HE and Safranin O\u2010fast green staining), immunofluorescent double staining, TUNEL stain, and Western blots were used to assess the morphological changes within AC and SM tissues in healthy and mild, moderate, or severe OA rats. Our results showed that the damage to AC and SM within the joints progressively worsened in different degrees during the course of the disease, and that the innate immune system was closely involved in the AC and SM during each stage of OA. These findings also confirmed that SM may affect the pathological changes in AC through the innate immune system, and therefore affect the progress of OA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26011","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T13:37:08Z","timestamp":1495028228000},"page":"1342-1358","source":"Crossref","is-referenced-by-count":39,"title":["Histomorphology and innate immunity during the progression of osteoarthritis: Does synovitis affect cartilage degradation?"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3678-2027","authenticated-orcid":false,"given":"Huan","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weili","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Ding","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhang","family":"Tang","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Ding","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfu","family":"Wang","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Beijing University of Chinese Medicine Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.02.092"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"9491","article-title":"Anindicator of subclinical cardiovascular disease in patients with primaryosteoarthritis: Epicardial fat thickness","volume":"8","author":"Belen E.","year":"2015","journal-title":"International Journal of Clinical & Experimental Medicine"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2099"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.202"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel111"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00286"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2640"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.08.027"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072494"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874312901206010220"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.04.017"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.60.175"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1863"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.009225"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.016"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.4.1760"},{"key":"e_1_2_7_18_1","first-page":"16","article-title":"Indices of severity in osteoarthritis for weight bearing joints","volume":"27","author":"Lequesne M. G.","year":"1991","journal-title":"Journal of Rheumatology Supplement"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8402-y"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-013-0323-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835a9428"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06246"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1998.0224"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904700304"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.140382"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.12.018"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20110418"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.150243"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0258"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.02.012"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.159"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.023044"},{"issue":"4","key":"e_1_2_7_33_1","first-page":"71","article-title":"Measurement of TLR\u2010induced macrophage spreading by automated image analysis: Differential role of Myd88 and MAPK in early and late responses","volume":"2","author":"Wenzel J.","year":"2011","journal-title":"Frontiers in Physiology"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0812390"},{"issue":"3","key":"e_1_2_7_35_1","first-page":"1633","article-title":"Differential toll\u2010like receptor\u2010dependent collagenase expression in chondrocytes","volume":"67","author":"Zhang Q.","year":"2007","journal-title":"Arthritis Research & Therapy"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.26011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26011","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.26011","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:39:48Z","timestamp":1693341588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.26011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,15]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1002\/jcp.26011"],"URL":"https:\/\/doi.org\/10.1002\/jcp.26011","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,15]]}}}