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Genetic variation in the Lp(a) locus and some other genes related to Lp(a) synthesis and metabolism play a critical role in regulating plasma Lp(a) levels. The pathophysiological potential of Lp(a) is related to proatherogenic and prothrombotic effects on the vasculature. Different molecular mechanisms underlying the atherothrombotic potential of Lp(a), free apolipoprotein(a), and oxidized\u2010Lp(a) have been proposed. However, plasma Lp(a) assay is complicated by problems associated with quantification and standardization owing to the polymorphic nature of this lipoprotein. This review has focused on the physicochemical properties of Lp(a), the genetic aspects of Lp(a), the need for accurate determination of Lp(a), the synthesis, and recent findings on metabolism of Lp(a). Lastly, the patho\u2010physiological mechanisms by which Lp(a) may increase athero\u2010thrombosis and an overview on the therapeutic modalities to interfere with Lp(a) are summarized.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26050","type":"journal-article","created":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T12:02:43Z","timestamp":1497355363000},"page":"2966-2981","source":"Crossref","is-referenced-by-count":71,"title":["Lipoprotein(a): A missing culprit in the management of athero\u2010thrombosis?"],"prefix":"10.1002","volume":"233","author":[{"given":"Gianna","family":"Ferretti","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences (DISCO) Polytechnic University of Marche Marche Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-9588","authenticated-orcid":false,"given":"Tiziana","family":"Bacchetti","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences (DISVA) Polytechnic University of Marche Marche Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Sciences School of Pharmacy University of Missouri\u2010Kansas City Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Department of Hypertension WAM University Hospital in Lodz Medical University of Lodz Lodz Poland"},{"name":"Polish Mother's Memorial Hospital Research Institute (PMMHRI) Lodz Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5527-4821","authenticated-orcid":false,"given":"Matteo","family":"Pirro","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine Angiology and Arteriosclerosis Diseases Department of Medicine University of Perugia Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.051"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.02.009"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb03514.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2002.009"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119753"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114519"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(93)90247-L"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800174-JLR200"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R060582"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500249-JLR200"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009744"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.020"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.07.019"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902604"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000143403"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61731-0"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715769209061085"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.114"},{"issue":"9","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0022-2275(20)40545-0","article-title":"Invivo fate and scavenger receptor recognition of oxidized lipoprotein[a] isoforms in rats","volume":"33","author":"Derijke Y. 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