{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:28:44Z","timestamp":1791440924554,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI15C0810"],"award-info":[{"award-number":["HI15C0810"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI17C0929"],"award-info":[{"award-number":["HI17C0929"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Apigenin is a plant\u2010derived flavonoid having antiproliferative, anti\u2010inflammatory, and anti\u2010angiogenic properties in chronic and metabolic diseases, and cancers. However, the functional role of apigenin remains to be identified in human endometriosis that is a benign inflammatory disease causing infertility, dysmenorrhea, dyspareunia, and chronic abdominal or pelvic pain. In the present study, we determined the effects of apigenin on two well\u2010established human endometriosis cell lines (VK2\/E6E7 and End1\/E6E7). Apigenin reduced proliferation and induced cell cycle arrest and apoptosis in the both endometriosis cell lines. In addition, it disrupted mitochondrial membrane potential (MMP) which was accompanied by an increase in concentration of calcium ions in the cytosol and in pro\u2010apoptotic proteins including Bax and cytochrome\n                      <jats:italic>c<\/jats:italic>\n                      in the VK2\/E6E7 and End1\/E6E7 cells. Moreover, apigenin treated cells accumulated excessive reactive oxygen species (ROS), and experienced lipid peroxidation and endoplasmic reticulum (ER) stress with activation of the unfolded protein response (UPR) regulatory proteins. Furthermore, the apigenin\u2010induced apoptosis in endometriosis cells was regulated via the ERK1\/2, JNK, and AKT cell signaling pathways. Taken together, apigenin is a potential novel therapeutic agent to overcome current limitations in the treatment to endometriosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26054","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T17:24:00Z","timestamp":1497547440000},"page":"3055-3065","source":"Crossref","is-referenced-by-count":76,"title":["Apigenin induces ROS\u2010dependent apoptosis and ER stress in human endometriosis cells"],"prefix":"10.1002","volume":"233","author":[{"given":"Sunwoo","family":"Park","sequence":"first","affiliation":[{"name":"Institute of Animal Molecular Biotechnology Korea University Seoul Republic of Korea"},{"name":"Department of Biotechnology College of Life Sciences and Biotechnology Korea University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whasun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Catholic Kwandong University Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W.","family":"Bazer","sequence":"additional","affiliation":[{"name":"Center for Animal Biotechnology and Genomics and Department of Animal Science Texas A&amp;M University College Station Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-5323","authenticated-orcid":false,"given":"Gwonhwa","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Animal Molecular Biotechnology Korea University Seoul Republic of Korea"},{"name":"Department of Biotechnology College of Life Sciences and Biotechnology Korea University Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.865136"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31450"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03112-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-015-9336-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.04.014"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401231"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp007"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1335.032"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00108-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/16729"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3694"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1362"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3665-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61590-8"},{"issue":"10","key":"e_1_2_6_17_1","first-page":"12557","article-title":"Apigenin inhibits TGF\u2010beta1\u2010induced proliferation and migration of airway smooth muscle cells","volume":"8","author":"Li L. 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