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In general, low bone mass, higher fracture risk, and increased marrow adipose tissue (MAT) are features of diabetic osteopathy in insulin\u2010deficient subjects. On the other hand, type 2 diabetes (T2DM) is associated with normal or high bone mass, a greater risk of peripheral fractures, and no change in MAT. Therefore, we sought to determine the effect of weight gain on bone turnover in insulin\u2010deficient mice. We evaluated the impact of a 6\u2010week high\u2010fat (HFD) rich in medium chain fatty acids or low\u2010fat diet (LFD) on bone mass and MAT in a streptozotocin (STZ)\u2010induced model using male C57BL\/6J mice at 8 weeks of age. Dietary intervention was initiated after diabetes confirmation. At the endpoint, lower non\u2010fasting glucose levels were observed in diabetic mice fed with high fat diet compared to diabetic mice fed the low fat diet (STZ\u2010LFD). Compared to euglycemic controls, the STZ\u2010LFD had marked polydipsia and polyphagia, as well as reduced lean mass, fat mass, and bone parameters. Interestingly, STZ\u2010HFD mice had higher bone mass, namely less cortical bone loss and more trabecular bone than STZ\u2010LFD. Thus, we found that a HFD, rich in medium chain fatty acids, protects against bone loss in a T1DM mouse model. Whether this may also translate to T1DM patients who are overweight or obese in respect to maintenance of bone mass remains to be determined through longitudinal studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26062","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T11:53:34Z","timestamp":1497959614000},"page":"1585-1600","source":"Crossref","is-referenced-by-count":24,"title":["High fat diet attenuates hyperglycemia, body composition changes, and bone loss in male streptozotocin\u2010induced type 1 diabetic mice"],"prefix":"10.1002","volume":"233","author":[{"given":"Adriana Lelis","family":"Carvalho","sequence":"first","affiliation":[{"name":"Center for Clinical and Translational Research Maine Medical Center Research Institute Scarborough Maine"},{"name":"Department of Internal Medicine Ribeir\u00e3o Preto Medical School University of S\u00e3o Paulo S\u00e3o Paulo 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