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This may be continued as dysfunction of the immune system, and ultimately result in secondary immune disorders. Studies have suggested a role for T cells in SM\u2010induced lung injury. Moreover, observations from animal studies indicate a delayed\u2010type hypersensitivity (DTH) response after skin exposure to SM, providing an understanding that SM can stimulate specific T cell\u2010mediated immune responses. On the other hand, T helper (Th) 17 cells, which are a subset of CD4+ T cells, have recently been reported to be involved in a number of inflammatory, autoimmune, and chronic fibrotic lung diseases. Furthermore, a strong association has been established between the overproduction of profibrotic cytokines like transforming growth factor (TGF)\u2010\u03b2 and Th17 cell number. In this review, we aimed to go through the new findings about the involvement and interactions of TGF\u2010\u03b2 and Th17 in SM\u2010related injuries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26077","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T12:37:46Z","timestamp":1498912666000},"page":"3037-3047","source":"Crossref","is-referenced-by-count":4,"title":["TGF\u2010\u03b2 and Th17 cells related injuries in patients with sulfur mustard exposure"],"prefix":"10.1002","volume":"233","author":[{"given":"Yunes","family":"Panahi","sequence":"first","affiliation":[{"name":"Chemical Injuries Research Center Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Ghanei","sequence":"additional","affiliation":[{"name":"Chemical Injuries Research Center Baqiyatallah University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Hassani","sequence":"additional","affiliation":[{"name":"Department of Hematology School of Allied Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1496"},{"issue":"3","key":"e_1_2_4_3_1","first-page":"147","article-title":"Smad molecules expression pattern in human bronchial airway induced by sulfur mustard","volume":"10","author":"Adelipour M.","year":"2011","journal-title":"Iranian Journal of Allergy, Asthma and Immunology"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207577200"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00169.2003"},{"key":"e_1_2_4_6_1","article-title":"Immunostatus of people exposed to sulfur mustard","author":"Al\u2010Yassin A.","year":"1984","journal-title":"Chemical Warfare Book"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.08.025"},{"issue":"1","key":"e_1_2_4_8_1","first-page":"5","article-title":"Sardasht\u2010Iran cohort study of chemical warfare victims: Design and methods","volume":"12","author":"Aragizadeh H.","year":"2009","journal-title":"Archives of Iranian Medicine"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2007.08.016"},{"key":"e_1_2_4_10_1","first-page":"335","article-title":"Interleukin\u20106 and airflow limitation in chemical warfare patients with chronic obstructive pulmonary disease","volume":"5","author":"Attaran D.","year":"2010","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.26"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37865"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1500"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/096032719901800203"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1385\/CBB:43:1:131"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.01.014"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210429200"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.015"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00390.2007"},{"issue":"3","key":"e_1_2_4_21_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00250978","article-title":"Effect of sulfur exposure on protease activity in human peripheral blood lymphocytes","volume":"7","author":"Cowan F. 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