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Identification of agents that can effectively suppress excessive osteoclast formation and function is crucial for prevention and treatment of osteolytic conditions such as periprosthetic joint infection and periprosthetic loosening. Luteoloside, a flavonoid, is a natural bioactive compound with anti\u2010inflammation and anti\u2010tumor properties. However, the effect of Luteoloside on inflammation\u2010induced osteolysis is unknown. Here, we found that Luteoloside exhibited a strong inhibitory effect on lipopolysaccharide (LPS)\u2010induced osteolysis in vivo. In addition, Luteoloside suppressed RANKL\u2010induced osteoclast differentiation and abrogated bone resorption in a dose\u2010dependent manner. Further, we found that the anti\u2010osteoclastic and anti\u2010resorptive actions of Luteoloside are mediated via blocking NFATc1 activity and the attenuation of RANKL\u2010mediated Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signaling as well as NF\u2010\u03baB and MAPK pathways. Taken together, this study shows that Luteoloside may be a potential therapeutic agent for osteolytic bone diseases associated with abnormal osteoclast formation and function in inflammatory conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26084","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T07:04:28Z","timestamp":1499324668000},"page":"1723-1735","source":"Crossref","is-referenced-by-count":47,"title":["Luteoloside prevents lipopolysaccharide\u2010induced osteolysis and suppresses RANKL\u2010induced osteoclastogenesis through attenuating RANKL signaling cascades"],"prefix":"10.1002","volume":"233","author":[{"given":"Fangming","family":"Song","sequence":"first","affiliation":[{"name":"Research Centre for Regenerative Medicine Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning Guangxi China"},{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-6863","authenticated-orcid":false,"given":"Chengming","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Centre for Regenerative Medicine Guangxi Key Laboratory of Regenerative Medicine Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences The University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Surgery Shanghai Key Laboratory of Orthopaedic Implant Shanghai Ninth People's Hospital Shanghai Jiaotong University School of Medicine Shanghai 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