{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:02:36Z","timestamp":1774976556511,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T00:00:00Z","timestamp":1506556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2015005588"],"award-info":[{"award-number":["2015005588"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:label\/><jats:p>Salivary dysfunction commonly occurs in many older adults and is considered a physiological phenomenon. However, the genetic changes in salivary glands during aging have not been characterized. The present study analyzed the gene expression profile in salivary glands from accelerated aging klotho deficient mice (klotho\u2212\/\u2212, 4 weeks old). Microarray analysis showed that 195 genes were differentially expressed (z\u2010score\u2009&gt;\u20092 in two independent arrays) in klotho null mice compared to wild\u2010type mice. Importantly, alpha2\u2010Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase (Atp1a2), Ca<jats:sup>2+<\/jats:sup>\u2010ATPase (Atp2a1), epidermal growth factor (EGF), and nerve growth factor (NGF), which have been suggested to be regulators of submandibular salivary gland function, were significantly decreased. When a network was constructed from the differentially expressed genes, proliferator\u2010activated receptor\u2010\u03b3 (PPAR \u03b3), which regulates energy homeostasis and insulin sensitivity, was located at the core of the network. In addition, the expression of genes proposed to regulate various PPAR \u03b3\u2010related cellular pathways, such as Klk1b26, Egfbp2, Cox8b, Gpx3, Fabp3, EGF, and NGF\u03b2, was altered in the submandibular salivary glands of klotho\u2212\/\u2212 mice. Our results may provide clues for the identification of novel genes involved in salivary gland dysfunction. Further characterization of these differentially expressed genes will be useful in elucidating the genetic basis of aging\u2010related changes in the submandibular salivary gland.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26172","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T12:32:47Z","timestamp":1504873967000},"page":"3282-3294","source":"Crossref","is-referenced-by-count":8,"title":["Global analysis of gene expression profiles in the submandibular salivary gland of klotho knockout mice"],"prefix":"10.1002","volume":"233","author":[{"given":"Sung\u2010Min","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, College of Dentistry Wonkwang University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo\u2010A","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Oriental Medicine Dongguk University Gyeongju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Hoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, College of Dentistry Wonkwang University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010In","family":"Yook","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Yonsei University College of Dentistry Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5837-7527","authenticated-orcid":false,"given":"Sang\u2010Gun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Dentistry Chosun University Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.025"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1994.0059"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.10.019"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/108076803322660495"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.53.082901.104018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199909)180:3<422::AID-JCP13>3.0.CO;2-T"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2013.07.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.59566\/IJBS.2014.10085","article-title":"Brain Na+, K + \u2212ATPase activity in aging and disease","volume":"10","author":"De Lores Arnaiz G. 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