{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:56:13Z","timestamp":1768686973724,"version":"3.49.0"},"reference-count":94,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Pulmonary hypertension (PH) is a life\u2010threatening lung disorder with towering prevalence and risk for future has been gradually rising worldwide. Even, no specific medications are available for pulmonary hypertension; various classes of treatment based upon the origin and magnitude of hypertension are still used for the treatment of PH. Consideration of molecular or signaling modulation is the imperative approach that can offer a new notion for prevalent pharmacotherapeutic agents. Instead of concurrent targets, including endothelin receptor antagonists (ETA\/ETB), phosphodiesterase 5 inhibitor (PDF\u20105), calcium channel blockers, anticoagulants, diuretics, and long acting prostacyclin analog, recent scientific reports revealed the numerous potential alternative therapeutic approaches that can significantly target the pathological signaling alteration associated with PH. Understanding precise molecular cascade involved in PH can be useful for designing preclinical animal experiments and human clinical trials to evaluate target specific novel therapeutic interventions for the treatment of PH. In this review, we discussed the possible molecular signaling involved in the pathogenesis of PH and detailed account of the current status of medications employed for the treatment of PH. Moreover, the newly identified potential target sites and alternative approaches for treating the PH have been discussed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26191","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T14:12:39Z","timestamp":1505830359000},"page":"3794-3804","source":"Crossref","is-referenced-by-count":10,"title":["Pulmonary hypertension: Molecular aspects of current therapeutic intervention and future direction"],"prefix":"10.1002","volume":"233","author":[{"given":"Taruna K.","family":"Arora","sequence":"first","affiliation":[{"name":"Indo Soviet College of Pharmacy Moga Punjab"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit K.","family":"Arora","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Sir Ganga ram Hospital New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika K.","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Fatima College of Health Sciences Alain UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyendra K.","family":"Rajput","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Pharmacology Amity University Noida Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5692-6502","authenticated-orcid":false,"given":"Arun K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Pharmacology Amity University Noida Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000352"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16769"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/687304"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1653708"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-015-1205-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.11.010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0196OC"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.05.048"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.03.010"},{"key":"e_1_2_7_11_1","first-page":"432","article-title":"[Therapeutic effect of radix Astragali on hypoxia pulmonary hypertension in rats]","volume":"22","author":"Chen X.","year":"1997","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12180"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5339\/gcsp.2014.29"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.93"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097754"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.133397"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt064"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.06.011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00002007"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca.13.6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-1174"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/01902148.2016.1181122"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00271.2013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA10366A"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12452"},{"key":"e_1_2_7_26_1","first-page":"340","article-title":"[Preventive and therapeutic effect of Chinese herbs naofeikang on experimental emphysema and pulmonary artery hypertension in hamsters]","volume":"22","author":"Han X.","year":"2000","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000508"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009526"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088946"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.308929"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-015-0125-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001324"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360182"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.07.011"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.01.006"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-013-1174-z"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12362"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2017.03.009"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0374OC"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-014-0310-1"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15494"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009309"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S75122"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0428OC"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2016.1254225"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-011-0592-0"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X14500827"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/374075"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00177.2015"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-016-1449-2"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-017-0220-9"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703570"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0514-0"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00707"},{"key":"e_1_2_7_55_1","article-title":"Effect of bosentan therapy in persistent pulmonary hypertension of the newborn","author":"Maneenil G.","year":"2017","journal-title":"Pediatrics and Neonatology"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E16-11-0790"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/573432"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.07.029"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.964207"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14608"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2017.05.003"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq170"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1311060"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00130209"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0b013e3181cbcbf3"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650080307"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.06.015"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.03.003"},{"key":"e_1_2_7_69_1","first-page":"857","article-title":"Effects of fluoxetine on nogo expression and collagen production with decrease of pulmonary artery pressure in rats with right ventricular failure","volume":"47","author":"Ran X.","year":"2016","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_7_70_1","first-page":"391","article-title":"Prostacyclin therapy for pulmonary arterial hypertension","volume":"37","author":"Ruan C. H.","year":"2010","journal-title":"Texas Heart Institute Journal"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X16500439"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.01.022"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA07927F"},{"key":"e_1_2_7_74_1","first-page":"264","article-title":"Apoptosis: A potential target site for natural bioactive agents during myocardial infarction","volume":"4","author":"Sharma A. K.","year":"2014","journal-title":"Journal of Advanced Pharmaceutical Technology & Research"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.01.053"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA03890E"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9070761"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00270.2003"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2012.07.011"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v7.i11.719"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00384.2006"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170606"},{"key":"e_1_2_7_83_1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/j.2040-4603.2011.tb00329.x","article-title":"Smooth muscle cell hypertrophy, proliferation, migration and apoptosis in pulmonary hypertension","volume":"1","author":"Tajsic T.","year":"2011","journal-title":"Comprehensive Physiology"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e3281a032a3"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31806befe6"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1188664"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4243"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.09.016"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4568"},{"key":"e_1_2_7_90_1","first-page":"97","article-title":"Effect of levcromakalim and cromakalim on ATP\u2010sensitive K+ channel of pulmonary arterial smooth muscle cells in pulmonary hypertensive rats","volume":"26","author":"Xiao X. R.","year":"2003","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.03.031"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2017.06.010"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-015-0124-z"},{"key":"e_1_2_7_94_1","first-page":"325","article-title":"[Influence of Erigeron breviscapus on the expression of collagen type I, MMP1 and TIMP1 of MRC\u20105 cells under hypoxia]","volume":"43","author":"Zheng J.\u2010Q.","year":"2012","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1674-8301(11)60052-3"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.26191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26191","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.26191","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T20:24:16Z","timestamp":1750883056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.26191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,27]]},"references-count":94,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/jcp.26191"],"URL":"https:\/\/doi.org\/10.1002\/jcp.26191","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,27]]}}}