{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:03:38Z","timestamp":1788959018885,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T00:00:00Z","timestamp":1514505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:label\/><jats:p>Concanavalin A (ConA)\u2010induced hepatitis is an experimental model of human autoimmune hepatitis induced in rodents by i.v. injection of Con A. The disease is characterized by increase in serum levels of transaminases and massive immune infiltration of the livers. Type 1, type 2, and type 17 cytokines play a pathogenic role in the development of ConA\u2010induced hepatitis. To understand further the immunoregulatory mechanisms operating in the development and regulation of ConA\u2010induced hepatitis, we have evaluated the role of the anti\u2010inflammatory pathway Nrf2\/HO\u20101\/CO (Nuclear Factor E2\u2010related Factor 2\/Heme Oxygenase\u20101\/Carbon Monoxide) in this condition and determined whether the in vivo administration of CO via the CO\u2010releasing molecule (CORM) CORM\u2010A1, influences serological and histological development of Con\u2010A\u2010induced hepatitis. We have firstly evaluated in silico the genes belonging to the Nrf2\/HO\u20101\/CO pathway that are involved in the pathogenesis of autoimmune hepatitis (AIH). The data obtained from the in silico study demonstrate that a significant number of genes modulated in the liver of ConA\u2010challenged mice belong to the Nrf2 pathway; on the other hand, the administration of CORM\u2010A1 determines an improvement in several sero\u2010immunological and histological parameters, and it is able to modulate genes identified by the in silico analysis. Collectively, our data indicate that the Nrf2\/HO\u20101\/CO pathway is fundamental for the regulation of the immune responses, and that therapeutic intervention aimed at its modulation by CORM\u2010A1 may represent a valuable strategy to be considered for the treatment of autoimmune hepatitis in humans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26223","type":"journal-article","created":{"date-parts":[[2017,10,16]],"date-time":"2017-10-16T04:26:42Z","timestamp":1508128002000},"page":"4156-4165","source":"Crossref","is-referenced-by-count":54,"title":["Involvement of the Nrf2\/HO\u20101\/CO axis and therapeutic intervention with the CO\u2010releasing molecule CORM\u2010A1, in a murine model of autoimmune hepatitis"],"prefix":"10.1002","volume":"233","author":[{"given":"Katia","family":"Mangano","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santa","family":"Mammana","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sofia","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Caltabiano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pesce","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Puleo","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanas G.","family":"Atanasov","sequence":"additional","affiliation":[{"name":"The Institute of Genetics and Animal Breeding Polish Academy of Sciences Jastrz\u0119biec Magdalenka Poland"},{"name":"Faculty of Life Sciences, Department of Pharmacognosy University of Vienna Vienna Austria"},{"name":"Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Magro","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4570-8462","authenticated-orcid":false,"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fagone","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26071"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783597362"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701311344"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300304"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-11-240"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28844"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939908994050"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21498"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04303.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04491.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.02.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302067"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26583"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084800"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.1.36-45.2004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63365-2"},{"issue":"8","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.4049\/jimmunol.160.8.4082","article-title":"Disparate roles for TNF\u2010alpha and Fas ligand in concanavalin A\u2010induced hepatitis","volume":"160","author":"Ksontini R.","year":"1998","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00209.2003"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2014.00032"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12124"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2169fje"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3228"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1999.0561"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2000.17701"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1997.4091423.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn079"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.8.4744"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-015-0834-9"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.06.011"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1948"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-009-9106-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368765"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.034"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25790"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115836"},{"issue":"3","key":"e_1_2_6_37_1","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.4049\/jimmunol.159.3.1537","article-title":"Requirement of IL\u20104 and liver NK1+ T cells for concanavalin A\u2010induced hepatic injury in mice","volume":"159","author":"Toyabe S.","year":"1997","journal-title":"Journal of Immunology (Baltimore, Md.: 1950)"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(15)60044-3"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.59"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.01.005"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.04.032"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.26223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.26223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:23:48Z","timestamp":1693398228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.26223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,29]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1002\/jcp.26223"],"URL":"https:\/\/doi.org\/10.1002\/jcp.26223","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,29]]}}}