{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:28:29Z","timestamp":1787124509964,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560046"],"award-info":[{"award-number":["81560046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2016GXNSFAA380002"],"award-info":[{"award-number":["2016GXNSFAA380002"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>We investigated the role of mammalian target of rapamycin\/nuclear factor\u2010kappa B (mTOR\/NF\u2010\u03baB) signaling pathway in high thoracic epidural anesthesia (HTEA) against myocardial ischemia\u2010reperfusion (I\/R) injury in rats. The rat model of myocardial I\/R injury was established. Ninety rats were divided into the normal, sham, I\/R, eHTEA, the PDTC, and HTEA\u2009+\u2009PDTC groups. ELISA was applied to detect cardiac function indexes. HE staining was conducted to observe histopathological changes of myocardial tissues, and TTC staining was performed to detect the myocardial infarction size. TUNEL staining was adopted to detect the cell apoptosis rate. The mRNA and protein levels of mTOR, NF\u2010\u03baB, Fasl, Bcl\u20102 and Bax, and LC3\u2010I, LC3\u2010II, BNIP3, and Atg5 were detected by RT\u2010qPCR and Western blotting, respectively. The findings indicated that compared with the normal and sham groups, the I\/R, PDTC, and HTEA groups showed the larger myocardial infarction size and increased cell apoptosis rate, while the results in the HTEA\u2009+\u2009PDTC group were opposite. Compared with the normal and sham groups, the I\/R group showed reduced mRNA and protein levels of Bcl\u20102, LC3, BNIP3, and Atg5, and elevated mRNA and protein levels of mTOR, p50, p65, Bax, and Fasl, while the HTEA\u2009+\u2009PDTC group revealed the opposite results, and the PDTC and HTEA group revealed the increased mRNA and protein levels of Bcl\u20102, LC3, BNIP3, Atg5, mTOR, p50, p65, Bax, and Fasl. These results prove that the inhibition of mTOR\/NF\u2010\u03baB signaling pathway potentiates HTEA against myocardial IR injury by autophagy and apoptosis in rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26320","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T09:36:35Z","timestamp":1512466595000},"page":"6669-6678","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Retracted<\/i>\n                    : Effects of mTOR\/NF\u2010\u03baB signaling pathway and high thoracic epidural anesthesia on myocardial ischemia\u2010reperfusion injury via autophagy in rats"],"prefix":"10.1002","volume":"233","author":[{"given":"Wei\u2010Qiang","family":"Huang","sequence":"first","affiliation":[{"name":"Cardio\u2010Cerebrovascular Disease Precision Medical Key Laboratory Cultivation Base of Guangxi Department of Geriatric Cardiology The First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Lin","family":"Wen","sequence":"additional","affiliation":[{"name":"Cardio\u2010Cerebrovascular Disease Precision Medical Key Laboratory Cultivation Base of Guangxi Department of Geriatric Cardiology The First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ri\u2010Qi","family":"Lin","sequence":"additional","affiliation":[{"name":"Cardio\u2010Cerebrovascular Disease Precision Medical Key Laboratory Cultivation Base of Guangxi Department of Geriatric Cardiology The First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wei","sequence":"additional","affiliation":[{"name":"Cardio\u2010Cerebrovascular Disease Precision Medical Key Laboratory Cultivation Base of Guangxi Department of Geriatric Cardiology The First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4300-5269","authenticated-orcid":false,"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Cardio\u2010Cerebrovascular Disease Precision Medical Key Laboratory Cultivation Base of Guangxi Department of Cardiology The First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715206113139990078"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24362"},{"issue":"23","key":"e_1_2_7_4_1","article-title":"Thoracic epidural anesthesia decreases endotoxin\u2010induced endothelial injury","volume":"14","author":"Enigk F.","year":"2014","journal-title":"BMC 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