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Apelin is endogenous ligand of APJ extracted from bovine stomach tissue in 1998. Apelin\/APJ system is widely expressed in many kinds of cells such as endothelial cells, cardiomyocytes, especially vascular smooth muscle cell. Vascular smooth muscle cell (VSMC), an integral part of the vascular wall, takes part in many normal physiological processes. Our experiment firstly finds that apelin\/APJ system enhances VSMC proliferation by ERK1\/2\u2010cyclin D1 signal pathway. Accumulating studies also show that apelin\/APJ system plays a pivotal role in mediating the function of VSMC. In this paper, we review the exact role of apelin\/APJ system in VSMC, including induction of proliferation and migration, enhance of contraction and relaxation, inhibition of calcification. Furthermore, we discuss the role of apelin\/APJ system in vascular diseases, such as atherosclerosis, hypertension, and chronic kidney disease (CKD) from the point of VSMC. Above all, apelin\/APJ system is a promising target for managing vascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26339","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T11:32:57Z","timestamp":1512646377000},"page":"5180-5188","source":"Crossref","is-referenced-by-count":37,"title":["Apelin\/APJ system: A critical regulator of vascular smooth muscle cell"],"prefix":"10.1002","volume":"233","author":[{"given":"Xuling","family":"Luo","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Pharmacology University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Pharmacology University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Pharmacology University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2787-3018","authenticated-orcid":false,"given":"Linxi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Pharmacology University of South China Hengyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000133194.94939.42"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578781"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kww095"},{"issue":"2","key":"e_1_2_8_5_1","first-page":"125","article-title":"Treatment\u2010associated change in apelin concentration in patients with hypertension and its relationship with left ventricular diastolic function","volume":"17","author":"Baysal S. 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