{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:48:23Z","timestamp":1762145303440,"version":"3.37.3"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016T91014"],"award-info":[{"award-number":["2016T91014"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600975"],"award-info":[{"award-number":["81600975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20150555"],"award-info":[{"award-number":["BK20150555"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Previous studies have shown that the Wnt\/\u03b2\u2010catenin signaling pathway plays an important role in modulating neuropathic pain after sciatic nerve injury. In this study, we explored the role of secreted frizzled\u2010related protein 1 (SFRP1), a Wnt antagonist, in neuropathic pain using a mouse model following spinal nerve ligation (SNL). We found SNL\u2010induced SFRP1 downregulation in the spinal cord. Further, overexpression of SFRP1 via spinal injection into the spinal cord attenuated SNL\u2010induced allodynia, hyperalgesia, and neuroinflammation. Consistently, in vitro assays also showed decreased expression of SFRP1 in spinal cord astrocytes after exposure to lipopolysaccharide (LPS). Overexpression of SFRP1 significantly alleviated the secretion of LPS\u2010induced proinflammatory factors in spinal cord astrocytes. Furthermore, spinal injection of LPS\u2010treated astrocytes induced allodynia and hyperalgesia, which were reversed by the overexpression of SFRP1 in these cells. Additionally, SNL increased Wnt3a and \u03b2\u2010catenin levels and also induced an increase in nuclear expression of \u03b2\u2010catenin; these effects were all attenuated by SFRP1. Finally, we found that downregulation of SFRP1, mainly through DNA methylation, is involved in the pathogenesis of neuropathic pain. Taken together, these results suggested that the SFRP1\/Wnt3a\/\u03b2\u2010catenin signaling pathway might be a suitable therapeutic target for neuropathic pain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26358","type":"journal-article","created":{"date-parts":[[2017,12,7]],"date-time":"2017-12-07T14:34:48Z","timestamp":1512657288000},"page":"5815-5822","source":"Crossref","is-referenced-by-count":21,"title":["Secreted frizzled\u2010related protein 1 regulates the progression of neuropathic pain in mice following spinal nerve ligation"],"prefix":"10.1002","volume":"233","author":[{"given":"Jun","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu Province P. R. 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