{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:59:08Z","timestamp":1769759948380,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["105-2314-B-039-001"],"award-info":[{"award-number":["105-2314-B-039-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:label\/><jats:p>Systemic inflammation induced by bacterial infection is one of several causative agents for cardiovascular disorders in patients with periodontal disease. Experimental results indicate that miRNAs play important roles in systemic inflammation induced by endotoxins. Further evidence states that stem cell based therapy shows potential in the treatment of inflammatory responses induced by sepsis. This study investigates if stem cells show protective effects on cardiomyocyte damage induced by porphyromonas gingivalis\u2010LPS (Pg\u2010LPS) through regulating miRNAs. H9c2 cardiomyoblasts and neonatal rat cardiomyocytes (NRCMs) were damaged using Pg\u2010LPS in this study. Pg\u2010LPS damaged H9c2 or NRCMs were then rescued using adipose\u2010derived stem cells (ADSC). The experimental results reveal that Pg\u2010LPS treatment is capable of inducing TLR4\/NF\u03baB axis activation, cell death signaling and IGF1R\/PI3\u2009K\/Akt axis suppression. miR181b was downregulated in Pg\u2010LPS damaged H9c2\/NRCMs. All markers were improved in H9c2\/NRCMs cocultured with ADSC. miR181b mimic and inhibitor confirmed that miR181b plays a central role in regulating the cardio protective effect on Pg\u2010LPS damaged H9c2\/NRCMs cocultured with ADSC. miR181b acts as potential therapeutic marker in cardiomyopathy induced by Pg\u2010LPS. Transplantation of adipose\u2010derived stem cells show potential in the treatment of cardiomyopathy induced by porphyromonas gingivalis endotoxin via regulation of miR181b.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26386","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T13:12:40Z","timestamp":1512997960000},"page":"5869-5876","source":"Crossref","is-referenced-by-count":13,"title":["Stem cells rescue cardiomyopathy induced by <i>P. gingivalis<\/i>\u2010LPS via miR\u2010181b"],"prefix":"10.1002","volume":"233","author":[{"given":"Tung\u2010Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"School of Life Science National Taiwan Normal University Taipei Taiwan"},{"name":"Graduate Institute of Basic Medical Science China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarnai","family":"Battsengel","sequence":"additional","affiliation":[{"name":"Graduate Institute of Basic Medical 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