{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:58:45Z","timestamp":1785376725238,"version":"3.55.0"},"reference-count":120,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Lung diseases are major cause of morbidity and mortality worldwide. The progress in regenerative medicine and stem cell research in the lung are currently a fast\u2010growing research topic that can provide solutions to these major health problems. Under normal conditions, the rate of cellular proliferation is relatively low in the lung in vivo, compared to other major organ systems. Lung injury leads to the activation of stem\/progenitor cell populations that re\u2010enter the cell cycle. Yet, little is known about stem cells in the lung, despite common thoughts that these cells could play a critical role in the repair of lung injuries. Nor do we fully understand the cellular and architectural complexity of the respiratory tract, and the diverse stem\/progenitor cells that are involved in the lung repair and regeneration. In this review, we discuss the conceptual framework of lung stem\/progenitor cell biology, and describe lung diseases, in which stem cell manipulations may be physiologically significant. In addition, we highlight the challenges of lung stem cell\u2010based therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26414","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T03:39:15Z","timestamp":1514086755000},"page":"6414-6424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Stem cells in lung repair and regeneration: Current applications and future promise"],"prefix":"10.1002","volume":"233","author":[{"given":"Yuqing","family":"Zhu","sequence":"first","affiliation":[{"name":"Centre of Stem cell and Regenerative Medicine, Schools of Medicine and Basic Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre of Stem cell and Regenerative Medicine, Schools of Medicine and Basic Medicine Zhejiang University  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Section of Environmental Biomedicine, School of Life Science Central China Normal University  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0146-4056","authenticated-orcid":false,"given":"Ahmed","family":"EI\u2010Hashash","sequence":"additional","affiliation":[{"name":"Centre of Stem cell and Regenerative Medicine, Schools of Medicine and Basic Medicine Zhejiang University  Hangzhou Zhejiang China"},{"name":"University of Edinburgh\u2010Zhejiang University Institute (UoE\u2010ZJU Institute)  Haining Zhejiang China"},{"name":"Edinburgh Medical School University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240310003576"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1574888\u2009(12666170914113633"},{"issue":"3","key":"e_1_2_11_4_1","first-page":"569","article-title":"Origin of ciliated alveolar epithelial cells in bleomycin\u2010induced lung injury","volume":"87","author":"Adamson I. 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