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However, this promise has not been fully realized and systemic administration of viruses has not proven as successful as envisioned in the clinical arena. Our research is focused on developing the next generation of efficacious viruses to specifically treat both primary cancers and a major cause of cancer lethality, metastatic tumors (that have spread from a primary site of origin to other areas in the body and are responsible for an estimated 90% of cancer deaths). We have generated a chimeric tropism\u2010modified type 5 and 3 adenovirus that selectively replicates in cancer cells and simultaneously produces a secreted anti\u2010cancer toxic cytokine, melanoma differentiation associated gene\u20107\/Interleukin\u201024 (<jats:italic>mda\u20107\/IL\u201024<\/jats:italic>), referred to as a Cancer Terminator Virus (CTV) (Ad.5\/3\u2010CTV). In preclinical animal models, injection into a primary tumor causes selective cell death and therapeutic activity is also observed in non\u2010injected distant tumors, that is, \u201cbystander anti\u2010tumor activity.\u201d To enhance the impact and therapeutic utility of the CTV, we have pioneered an elegant approach in which viruses are encapsulated in microbubbles allowing \u201cstealth delivery\u201d to tumor cells that when treated with focused ultrasound causes viral release killing tumor cells through viral replication, and producing and secreting MDA\u20107\/IL\u201024, which stimulates the immune system to attack distant cancers, inhibits tumor angiogenesis and directly promotes apoptosis in distant cancer cells. This strategy is called UTMD (ultrasound\u2010targeted microbubble\u2010destruction). This novel CTV and UTMD approach hold significant promise for the effective therapy of primary and disseminated tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcp.26421","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T18:27:08Z","timestamp":1514312828000},"page":"5684-5695","source":"Crossref","is-referenced-by-count":20,"title":["Cancer terminator viruses (<i>CTV<\/i>): A better solution for viral\u2010based therapy of cancer"],"prefix":"10.1002","volume":"233","author":[{"given":"Luni","family":"Emdad","sequence":"first","affiliation":[{"name":"Department of Human and Molecular Genetics School of Medicine VCU Institute of Molecular Medicine and VCU Massey Cancer Center Virginia Commonwealth University Richmond Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swadesh K.","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Human and Molecular Genetics School of Medicine VCU Institute of Molecular 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