{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:29:20Z","timestamp":1790267360384,"version":"4.1.0"},"reference-count":106,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T00:00:00Z","timestamp":1520380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Bisphosphonates are considered the most effective drugs for controlling adult and pediatric osteolytic diseases. Although they have been used successfully for many years, several side effects, such as osteonecrosis of the jaw, delayed dental eruption, atypical femoral fracture, and alterations to the bone growth system, have been described. After an overview of nitrogenous bisphosphonate, the purpose of this article is to describe their mechanisms of action and current applications, review the preclinical and clinical evidence of their side effects in the skeleton (\u201cwhat we know\u201d), and describe current recommendations for preventing and managing these effects (\u201cwhat we can do\u201d). Finally, promising future directions on how to limit the occurrence of these side effects will be presented.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26465","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T11:58:35Z","timestamp":1515671915000},"page":"5696-5715","source":"Crossref","is-referenced-by-count":59,"title":["Paradoxical side effects of bisphosphonates on the skeleton: What do we know and what can we do?"],"prefix":"10.1002","volume":"233","author":[{"given":"Jorge W.","family":"Vargas\u2010Franco","sequence":"first","affiliation":[{"name":"UMR\u20101238, INSERM, Equipe 1 Facult\u00e9 de M\u00e9decine de l'Universit\u00e9 de Nantes Nantes France"},{"name":"Department of Basic Studies, Faculty of Odontology University of Antioquia Medellin Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Castaneda","sequence":"additional","affiliation":[{"name":"INSERM, UMR\u20101138, Equipe 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