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In this work, an integrated proteomics and bioinformatics approach was employed to identify differentially expressed proteins at the injury\u2010site of rat sciatic nerve at 20 days after damage. By a label\u2010free liquid chromatography mass\u2010spectrometry (LC\u2010MS\/MS) approach, we identified 201 differentially proteins that were assigned to specific canonical and disease and function pathways. These include proteins involved in cytoskeleton signaling and remodeling, acute phase response, and cellular metabolism. Metabolic proteins were significantly modulated after nerve injury to support a specific metabolic demand. In particular, we identified a group of proteins involved in lipid uptake and lipid storage metabolism. Immunofluorescent staining for acyl\u2010CoA diacylglycerol acyltransferase 1 (DGAT1) and DAGT2 expression provided evidence for the expression and localization of these two isoforms in Schwann cells at the injury site in the sciatic nerve. This further supports a specific local regulation of lipid metabolism in peripheral nerve after damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26478","type":"journal-article","created":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T03:40:33Z","timestamp":1515728433000},"page":"6207-6223","source":"Crossref","is-referenced-by-count":14,"title":["Proteomic expression profile of injured rat peripheral nerves revealed biological networks and processes associated with nerve regeneration"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-7674","authenticated-orcid":false,"given":"Daniele","family":"Vergara","sequence":"first","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies University of Salento Lecce Italy"},{"name":"Laboratory of Clinical Proteomic \u201cGiovanni Paolo II\u201d Hospital ASL\u2010Lecce Lecce 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