{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:37:55Z","timestamp":1784335075788,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Optic nerve injury triggered retinal ganglion cell (RGC) death and optic nerve atrophy lead to visual loss. Bone marrow mesenchymal stem cells (BMSCs) are stromal cells, capable of proliferating and differentiating into different types of tissues. This aims of this study is to investigate the role of BMSCs transfected with angiopoietin\u20101 (Ang\u20101) in optic nerve injury induced by hyperoxia in a neonatal mice model. Ang\u20101 overexpression vector was constructed and used to transfect BMSCs. Reverse transcription\u2010quantitative polymerase chain reaction was performed to detect Ang\u20101 expression in BMSCs. The hyperoxia\u2010induced optic nerve injury model was established. The optic nerves at 6\u20137\u2009mm posterior to the eyeball were extracted, and were treated with luxol fast blue staining, immunohistochemistry, immunofluorescence, and transmission electron microscopy to examine the effects of Ang\u20101\u2010modified BMSCs on optic nerve injury induced by hyperoxia. The mice in the Ang\u20101\u2009+\u2009BMSCs and BMSCs groups showed remarkably improved myelin sheaths of nerve fibers compared to the hyperoxia saline group. The positive expression and integrated optic density of Ang\u20101 in the Ang\u20101\u2009+\u2009BMSCs group were significantly higher compared to the air control, hyperoxia saline and BMSCs groups. The number and diameter of myelinated nerve fibers, the diameter of axons and the thickness of myelin sheath in the air control and Ang\u20101\u2009+\u2009BMSCs groups were higher compared to the hyperoxia saline group. Our study provides evidence supporting that Ang\u20101\u2010modified BMSCs may have preventive and therapeutic effects on hyperoxia\u2010induced optic nerve injury in neonatal mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26501","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T14:36:19Z","timestamp":1517236579000},"page":"8567-8577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of bone marrow mesenchymal stem cells transfected with Ang\u20101 gene on hyperoxia\u2010induced optic nerve injury in neonatal mice"],"prefix":"10.1002","volume":"233","author":[{"given":"Fang\u2010Yu","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Neurobiology, School of Basic Medical Science Anhui Medical University Hefei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Wu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, School of Basic Medical Science Anhui Medical University Hefei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Hua","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Affiliated Hospital of Binzhou Medical College Binzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, School of Basic Medical Science Anhui Medical University Hefei P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Fei","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, School of Basic Medical Science Anhui Medical University Hefei P.R. 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