{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:05:15Z","timestamp":1791515115029,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16H070008"],"award-info":[{"award-number":["LY16H070008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY17H160068"],"award-info":[{"award-number":["LY17H160068"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Balanced bone resorption and bone formation are vital for bone homeostasis. Excessive osteoclastic bone resorption in this process can cause a variety of bone disorders including osteoporosis, aseptic prosthetic loosening and tumor associated bone destruction. Bulleyaconitine A (BLA) is a natural compound that has been widely used for pain treatment but its role in osteolysis has not yet been investigated. In this study, we verified for the first time that BLA inhibited osteoclast formation, the mRNA expression of osteoclast\u2010related genes and osteoclastic bone resorption by inhibiting NF\u2010\u03baB signal pathway and downstream NFATc1 expression. Meanwhile, BLA had a stimulatory effect in osteoblast differentiation and mineralization. Furthermore, BLA showed preventive effect in Ti particle\u2010induced osteolysis model in vivo. Together, all our data demonstrated that BLA suppressed osteoclastogenesis and promoted osteoblastogenesis via suppressing NF\u2010\u03baB signal pathway and could be an alternative therapeutic choice against bone loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26508","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T06:12:42Z","timestamp":1517465562000},"page":"7067-7079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Bulleyaconitine A prevents Ti particle\u2010induced osteolysis via suppressing NF\u2010\u03baB signal pathway during osteoclastogenesis and osteoblastogenesis"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-9841","authenticated-orcid":false,"given":"Liwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"},{"name":"Enze Medical Research Center Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Central Hospital Affiliated to Taizhou University Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"},{"name":"Enze Medical Research Center Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[{"name":"Enze Medical Research Center Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binxiang","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"},{"name":"Enze Medical Research Center Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiting","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Enze Medical Research Center Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Lv","sequence":"additional","affiliation":[{"name":"Enze Medical Research Center Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Taizhou Hospital Affiliated to Wenzhou Medical University Linhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2170"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513500306"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1954"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132781"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.05.038"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2005.11.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M901670200"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.24.3482"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.04.252"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1197-1285"},{"key":"e_1_2_6_12_1","first-page":"1","article-title":"Wear and osteolysis in total joint replacements","volume":"278","author":"Kadoya Y.","year":"1998","journal-title":"Acta Orthopaedica Scandinavica. Supplementum"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2016.52.1.12"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0237"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X16670154"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070121"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2015.12.015"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45056"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.07.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.07.091"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_22_1","first-page":"171","article-title":"Periprosthetic osteolysis in total hip arthroplasty: The role of particulate wear debris","volume":"45","author":"Maloney W. J.","year":"1996","journal-title":"Instructional Course Lectures"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S46192"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.159"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042081"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13032877"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.177"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041213"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1504"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.08.010"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000267502.18605.ad"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23827"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.11.051"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302202"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3334"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.90064"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610701200"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2771"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.26508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.26508","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:14:31Z","timestamp":1787123671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.26508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,25]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jcp.26508"],"URL":"https:\/\/doi.org\/10.1002\/jcp.26508","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,25]]},"assertion":[{"value":"2017-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}