{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:29:01Z","timestamp":1787124541583,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>This study is supposed to investigate the effect of FGF\u201023 on parathyroid hormone (PTH) secretion through ERK\/MAPK signaling pathway in secondary hyperparathyroidism (SHPT) rat model. Thirty rats were equally served as the normal and SHPT groups. After transfection, parathyroid cells was assigned into blank, NC, pcDNA3.1\u2010FGF\u201023, siRNA\u2010FGF\u201023, U0126, and siRNA\u2010FGF\u201023\u2009+\u2009U0126 groups. The serum levels of Calcium (Ca), Phosphorus (P), alkaline phosphatase (ALP), and PTH were detected. HE and immunohistochemical (IHC) staining were used for the histopathological changes and the FGF\u201023, EKR1\/2, and pEKR1\/2 expressions. qRT\u2010PCR and Western blotting were performed to determine the mRNA and protein expression of FGF\u201023, PTH, MAPK, EKR1\/2, and Klotho. The proliferation, apoptosis, and cell cycle were all measured for parathyroid cells by CCK\u20108 assay, TUNEL staining and Flow cytometry. Compared with the normal group, the SHPT group showed increased serum levels PTH, P, ALP, and FGF\u201023 and mRNA and protein expressions of FGF\u201023 and PTH, whereas declined Ca and p\u2010ERK1\/2 expression, mRNA and protein expression of Klotho, cell apoptosis rate was reduced. Furthermore, compared to the blank and NC groups, the pcDNA3.1\u2010FGF\u201023 and U0126 groups had a decreased mRNA expression of Klotho, protein expression of EKR1\/2 and Klotho, and cell apoptosis rate was down\u2010regulated, whereas the RNA and protein expressions of FGF\u201023 and PTH were up\u2010regulated, and cell proliferation was elevated. The opposite results were observed in the siRNA\u2010FGF\u201023 group. Our study demonstrated that FGF\u201023 could inhibit signaling transduction of ERK\/MAPK pathway and accelerate the secretion of PTH in rats with SHPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26525","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T04:05:18Z","timestamp":1523333118000},"page":"7092-7102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of FGF\u201023\u2010mediated ERK\/MAPK signaling pathway on parathyroid hormone secretion of parathyroid cells in rats with secondary hyperparathyroidism"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-2061","authenticated-orcid":false,"given":"Xiao\u2010Jun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Soochow University Suzhou P.R. China"},{"name":"Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Wenzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Wenzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Wenzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical University Wenzhou P.R. 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