{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:00:23Z","timestamp":1789747223693,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T00:00:00Z","timestamp":1524009600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501094"],"award-info":[{"award-number":["81501094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Glioblastoma pathogenesis is related to multiple processes that affected by dozens of regulatory factors, but the potential underlying factors regulating glioblastoma progression remains unclear. The goal of this research was to determine how the ribonucleotide reductase M2 subunit (\n                      <jats:italic>RRM2<\/jats:italic>\n                      ) influenced proliferation, invasion, migration, and apoptosis of human glioblastoma cells. The level of proliferation of human glioblastoma cells was measured through CCK8, colony formation assay and immunofluorescence stains. Flow cytometry (FCM), wound healing, and transwell assays were conducted to detect cell apoptosis, migration, and invasion. Apoptotic level of cells and invasion\u2010related expression of protein were measured by Western blot. Xenograft tumor model was established to confirm effect of\n                      <jats:italic>RRM2<\/jats:italic>\n                      on the proliferation of human glioblastoma cells in vivo. Silencing\n                      <jats:italic>RRM2<\/jats:italic>\n                      inhibited proliferation, invasion, and migration of glioblastoma cells whereas enhanced apoptosis rate. Overexpressing\n                      <jats:italic>RRM2<\/jats:italic>\n                      promoted proliferation, migration and invasion but suppressed apoptosis. In vivo, Overexpressing\n                      <jats:italic>RRM2<\/jats:italic>\n                      accelerated the tumor growth in glioblastoma cells. The present study illustrated that\n                      <jats:italic>RRM2<\/jats:italic>\n                      was overexpressed in human glioblastoma cells.\n                      <jats:italic>RRM2<\/jats:italic>\n                      promoted proliferation, migration, and invasion but inhibited apoptosis of human glioblastoma cells.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26529","type":"journal-article","created":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T06:38:10Z","timestamp":1524033490000},"page":"6759-6767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["<i>RRM2<\/i>\n                    promotes the progression of human glioblastoma"],"prefix":"10.1002","volume":"233","author":[{"given":"Chao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Qilu Hospital Shandong University  Jinan Shandong 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