{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:40Z","timestamp":1791267280391,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81260082"],"award-info":[{"award-number":["81260082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Liver fibrosis is a reversible wound\u2010healing response that occurs after liver injury. NADPH oxidases (NOXs) and reactive oxygen species (ROS) which are expressed in hepatocytes (HCs), hepatic stellate cells (HSCs), and Kupffer cells (KCs) play an important role in the development of hepatic fibrosis. In in vitro studies, we had shown that ursolic acid (UA) could reverse liver fibrosis by inhibiting the activation of NOX\u2010mediated fibrotic signaling networks in HSCs. In this study, we verified that UA could alleviate CCl4\u2010induced liver fibrosis by reducing the expression of NOXs\/ROS in HCs, HSCs, KCs. Meanwhile, the phagocytic index \u03b1 and clearance index K which represent phagocytosis of KCs were unchanged. Together, all our data demonstrated that UA induced the proliferation of HCs, promoted apoptosis in HSCs, and prevented activation of KCs in vivo by reducing the expression of NOXs\/ROS in HCs, HSCs, KCs. Besides, UA had no effect on the host defense function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26541","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T15:15:27Z","timestamp":1524150927000},"page":"6799-6813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Ursolic acid ameliorates CCl4\u2010induced liver fibrosis through the NOXs\/ROS pathway"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4971-4325","authenticated-orcid":false,"given":"Dakai","family":"Gan","sequence":"first","affiliation":[{"name":"Department One of Liver Disease The Ninth Hospital of Nanchang  Nanchang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Nanchang University  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