{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:28:54Z","timestamp":1787124534701,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Long non\u2010coding RNAs (lncRNAs) have been validated to play important role in multiple cancers, including non\u2010small cell lung cancer (NSCLC). In present study, our team investigate the biologic role of SNHG15 in the NSCLC tumorigenesis. LncRNA SNHG15 was significantly upregulated in NSCLC tissue samples and cells, and its overexpression was associated with poor prognosis of NSCLC patients. In vitro, loss\u2010of\u2010functional cellular experiments showed that SNHG15 silencing significantly inhibited the proliferation, promoted the apoptosis, and induced the cycle arrest at G0\/\/G1 phase. In vivo, xenograft assay showed that SNHG15 silencing suppressed tumor growth of NSCLC cells. Besides, SNHG15 silencing decreased CDK14 protein expression both in vivo and vitro. Bioinformatics tools and luciferase reporter assay confirmed that miR\u2010486 both targeted the 3\u2032\u2010UTR of SNHG15 and CDK14 and was negatively correlated with their expression levels. In summary, our study conclude that the ectopic overexpression of SNHG15 contribute to the NSCLC tumorigenesis by regulating CDK14 protein via sponging miR\u2010486, providing a novel insight for NSCLC pathogenesis and potential therapeutic strategy for NSCLC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26543","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T16:20:05Z","timestamp":1523290805000},"page":"7164-7172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["RETRACTED: Long non\u2010coding RNA SNHG15 promotes CDK14 expression via miR\u2010486 to accelerate non\u2010small cell lung cancer cells progression and metastasis"],"prefix":"10.1002","volume":"233","author":[{"given":"Bing","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Chest Surgery Nanyang City Center Hospital Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Respiration Jinshan Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Fudan University Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-5920","authenticated-orcid":false,"given":"Jian\u2010Jun","family":"Xu","sequence":"additional","affiliation":[{"name":"Fudan University Yangpu District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-0315","authenticated-orcid":false,"given":"Bing","family":"Li","sequence":"additional","affiliation":[{"name":"Central Laboratory Jinshan Hospital Affiliated to Fudan University Jinshan District, Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788695"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0708"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S148443"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504017X14865126670075"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.11.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504016X14719078133203"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.062"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21465"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.04.019"},{"key":"e_1_2_7_12_1","first-page":"565","article-title":"The lncRNA MALAT1 contributes to non\u2010small cell lung cancer development via modulating miR\u2010124\/STAT3 axis","volume":"8","author":"Li S.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.01.036"},{"key":"e_1_2_7_14_1","first-page":"46","article-title":"LncRNA SNHG15 contributes to proliferation, invasion and autophagy in osteosarcoma cells by sponging miR\u2010141","volume":"24","author":"Liu K.","year":"2017","journal-title":"Journal of Biomedical Sciences"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.12.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.51"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504017X14883287513729"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5985"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20359"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1348-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504016X14822800040451"},{"key":"e_1_2_7_22_1","article-title":"Long noncoding RNAs: Emerging players in thyroid cancer pathogenesis","author":"Murugan A. 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