{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:28:35Z","timestamp":1787124515878,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      To explore the effects of IL\u20107\/IL\u20107R on the RANKL\u2010mediated osteoclast differentiation in vitro and OVX\u2010induced bone loss in vivo. BMMs and RAW264.7 were transfected with IL\u20107, IL\u20107R siRNA, c\u2010Fos siRNA, and c\u2010jun siRNA and later stimulated by RANKL. TRAP and toluidine blue staining were used to observe osteoclast formation and bone resorption, respectively. HE and TRAP staining were used to detect trabecular bone microstructure and osteoclasts of mice, respectively. qRT\u2010PCR and Western blot analysis were used to examine expression. IL\u20107 unregulated the expression of CTSK, NFATc1, MMP9, and the phosphorylation of p38 and Akt by activating the c\u2010Fos\/c\u2010Jun pathway, which increased osteoclast numbers and bone resorption in RANKL\u2010stimulated macrophages. While IL\u20107R siRNA and c\u2010Fos siRNA decreased the expression, as well as and the phosphorylation of p38 and Akt.IL\u20107 decreased the BMD and\n                      <jats:italic>OPG<\/jats:italic>\n                      expression in OVX\u2010induced mice and increased the TRAP positive cells, the mRNA expression of c\u2010fos, c\u2010jun, and\n                      <jats:italic>RANKL<\/jats:italic>\n                      , which was contradictory to IL\u20107R siRNA, and c\u2010Fos siRNA. Furthermore, IL\u20107R siRNA and c\u2010Fos siRNA caused thicker trabeculae, increased trabecular number, and decreased osteolysis in OVX mice. IL\u20107\/IL\u20107R can promote RANKL\u2010mediated osteoclast formation and bone resorption by activating the c\u2010Fos\/c\u2010Jun pathway, as well as inducing bone loss in OVX mice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26548","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:17:53Z","timestamp":1523924273000},"page":"7182-7194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of interleukin\u20107\/interleukin\u20107 receptor on RANKL\u2010mediated osteoclast differentiation and ovariectomy\u2010induced bone loss by regulating c\u2010Fos\/c\u2010Jun pathway"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8101-4858","authenticated-orcid":false,"given":"Ji\u2010Jun","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopedics Wuxi People's Hospital Wuxi Jiangsu Province P. 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