{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:44:57Z","timestamp":1787244297991,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Cervical cancer (CC) remains a highly prevalent cancer and mortality globally among women globally. The aim of the present study was to assess the ability of miR\u2010374b to regulate CC cells through JAM\u20102, whilst exploring whether the underlying mechanism and its relation to the p38\/ERK signaling pathway. During the study, microRNA\u2010374b (miR\u2010374b) was observed to have been expressed at a low level among CC tissues. Hence, a series of miR\u2010374b mimics, miR\u2010374b inhibitors, siRNA against JAM\u20102, SB202190 (an inhibitor for p38), and PD98059 (an inhibitor for ERK) were introduced to treat CC Siha cells and normal cervical Ect1\/E6E7 cells. MTT, flow cytometry, scratch test, and transwell assays were applied to determine cell viability, apoptosis, migration, and invasion. The inhibitory role of the p38\/ERK signaling pathway was observed in the CC cells treated with miR\u2010374b mimics or siRNA against JAM\u20102. miR\u2010374b mimic exposure was found to reduce cell viability, migration, and invasion, but induce apoptosis. MiR\u2010374b inhibitor exposure was observed to have induced effects on the CC cells in a contrary manner to those induced by that of the miR\u2010374b mimics. The key findings of the study demonstrated that miR\u2010374b significantly inhibits cell proliferation, migration, and invasion through the blockade of the p38\/ERK signaling pathway activation, as well as negatively binding to JAM\u20102, highlighting its potential as a therapeutic target for CC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26574","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:22:32Z","timestamp":1521984152000},"page":"7379-7390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["RETRACTED: MicroRNA\u2010374b inhibits cervical cancer cell proliferation and induces apoptosis through the p38\/ERK signaling pathway by binding to JAM\u20102"],"prefix":"10.1002","volume":"233","author":[{"given":"Guang\u2010Cai","family":"Li","sequence":"first","affiliation":[{"name":"Medical Insurance Management Office Linyi People's Hospital Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yun","family":"Cao","sequence":"additional","affiliation":[{"name":"Medical Insurance Management Office Economic and Technological Development Zone People's Hospital of Linyi Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Ni","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Economic and Technological Development Zone People's Hospital of Linyi Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010 Yan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Economic and Technological Development Zone People's Hospital of Linyi Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Na","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Economic and Technological Development Zone People's Hospital of Linyi Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Residency Office of Educational Department Linyi People's Hospital Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-2976","authenticated-orcid":false,"given":"Xiang\u2010Xiu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Linyi People's Hospital Linyi P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.10.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.05.027"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-015-0490-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/178075"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.17.7401"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4457"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6680"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3179"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0380-z"},{"issue":"2","key":"e_1_2_7_11_1","first-page":"403","article-title":"N\u2010WASP promotes invasion and migration of cervical cancer cells through regulating p38 MAPKs signaling pathway","volume":"9","author":"Hou J.","year":"2017","journal-title":"American Journal of Translational Research"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"441","article-title":"The proteasome subunit PSMA7 located on the 20q13 amplicon is overexpressed and associated with liver metastasis in colorectal cancer","volume":"19","author":"Hu X. T.","year":"2008","journal-title":"Oncology Reports"},{"issue":"5","key":"e_1_2_7_13_1","first-page":"1247","article-title":"Depletion of the proteasome subunit PSMA7 inhibits colorectal cancer cell tumorigenicity and migration","volume":"22","author":"Hu X. T.","year":"2009","journal-title":"Oncology Reports"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3289"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.07.150"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2016.1177676"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.20.8539"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4836"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6708"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007085"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.02.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2947"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.561"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.11.019"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.61.06.536"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.23"},{"issue":"6","key":"e_1_2_7_28_1","first-page":"8599","article-title":"TSPAN8 promotes gastric cancer growth and metastasis via ERK MAPK pathway","volume":"8","author":"Wei L.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"issue":"3","key":"e_1_2_7_29_1","first-page":"2840","article-title":"The potential value of miR\u20101 and miR\u2010374b as biomarkers for colorectal cancer","volume":"8","author":"Wu X.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"2","key":"e_1_2_7_30_1","first-page":"1804","article-title":"Stomatin\u2010like protein 2 expression is associated with clinical survival in patients with cervical cancer","volume":"8","author":"Xiao B.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i46.17439"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4773"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3340"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5038"}],"updated-by":[{"DOI":"10.1002\/jcp.70217","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000}}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.26574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.26574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:15:46Z","timestamp":1787123746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.26574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,25]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/jcp.26574"],"URL":"https:\/\/doi.org\/10.1002\/jcp.26574","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,25]]},"assertion":[{"value":"2017-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}