{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:28:34Z","timestamp":1787124514398,"version":"build-2736575974"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG2014\u201015690"],"award-info":[{"award-number":["IG2014\u201015690"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001755","name":"Mesothelioma Applied Research Foundation","doi-asserted-by":"publisher","award":["2016"],"award-info":[{"award-number":["2016"]}],"id":[{"id":"10.13039\/100001755","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Malignant mesothelioma (MM) is a very aggressive asbestos\u2010related cancer, whose incidence is increasing worldwide. Unfortunately, no effective therapies are currently available and the prognosis is extremely poor. Recently, the anti\u2010helminthic drug pyrvinium pamoate has attracted a strong interest for its anti\u2010cancer activity, which has been demonstrated in many cancer models. Considering the previously established inhibitory effect of pyrvinium pamoate on the Wnt\/\u03b2\u2010catenin pathway and given the important role of this pathway in MM, we investigated the potential anti\u2010tumor activity of this drug in MM cell lines. We observed that pyrvinium pamoate significantly impairs MM cell proliferation, cloning efficiency, migration, and tumor spheroid formation. At the molecular level, our data show that pyrvinium pamoate down\u2010regulates the expression of \u03b2\u2010catenin and Wnt\u2010regulates genes. Overall, our study suggests that the repurposing of pyrvinium pamoate for MM treatment could represent a new promising therapeutic approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26579","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T11:15:02Z","timestamp":1523877302000},"page":"7391-7401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Possible repurposing of pyrvinium pamoate for the treatment of mesothelioma: A pre\u2010clinical assessment"],"prefix":"10.1002","volume":"233","author":[{"given":"Marcella","family":"Barbarino","sequence":"first","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology College of Science and Technology Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Cesari","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Intruglio","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Indovina","sequence":"additional","affiliation":[{"name":"Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology College of Science and Technology Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asadoor","family":"Namagerdi","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca Maria","family":"Bertolino","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bottaro","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaram","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Bellan","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnologies University of Siena Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Medicine Surgery and Neuroscience University of Siena Siena Italy"},{"name":"Sbarro Institute for Cancer Research and Molecular Medicine Center for Biotechnology College of Science and Technology Temple University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Global trends in mortality from malignant mesothelioma; analysis of WHO mortality database (1994\u20132013)","volume":"00","author":"Abdel\u2010Rahman O.","year":"2018","journal-title":"The Clinical Respiratory Journal"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0642-x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-016-0003-3"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"1","article-title":"Toxicity of nanoparticles and an overview of current experimental models","volume":"20","author":"Bahadar H.","year":"2016","journal-title":"Iranian Biomedical Journal"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2016.04.007"},{"key":"e_1_2_7_7_1","first-page":"5126","article-title":"Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer","volume":"62","author":"Boon E. 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