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Exogenous zinc (Zn) was suggested as a potent antioxidant; however, the mechanism by which it strengthens the organ resistance against the effects of reactive oxygen species (ROS) is not yet investigated. The present study aims to determine whether acute zinc chloride (ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      ) administration could attenuate endoplasmic reticulum (ER) stress, autophagy, and inflammation after renal I\/R. Rats were subjected to either sham operation (Sham group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), or 1\u2009hr of bilateral ischemia followed by 2\u2009hr of reperfusion (I\/R groups,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096), or they received ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      orally 24\u2009hr and 30\u2009min before ischemia (ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Rats were subjected to 1\u2009hr of bilateral renal ischemia followed by 2\u2009hr of reperfusion (I\/R group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Our results showed that ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      enhances renal function and reduces cytolysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090,05). In addition, it increased significantly the activities of antioxidant enzymes (SOD, CAT, and GPX) and the level of GSH in comparison to I\/R (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090,05). Interestingly, ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      treatment resulted in significant decreased ER stress, as reflected by GRP78, ATF\u20106,p\u2010eIF\u20102\u03b1, XPB\u20101, and CHOP downregulaion. Rats undergoing ZnCl\n                      <jats:sub>2<\/jats:sub>\n                      treatment demonstrated a low expression of autophagy parameters (Beclin\u20101 and LAMP\u20102), which was correlated with low induction of apoptosis (caspase\u20109, caspase\u20103, and p\u2010JNK), and reduction of inflammation (IL\u20101\u00df, IL\u20106, and MCP\u20101) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090,05). In conclusion, we demonstrated the potential effect of Zn supplementation to modulate ER pathway and autophagic process after I\/R.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26747","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T07:47:13Z","timestamp":1526370433000},"page":"8677-8690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Zinc mitigates renal ischemia\u2010reperfusion injury in rats by modulating oxidative stress, endoplasmic reticulum stress, and autophagy"],"prefix":"10.1002","volume":"233","author":[{"given":"Najet","family":"Hadj Abdallah","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, Department of Physiology, Unit\u00e9 de Biologie et Anthropologie Mol\u00e9culaire Appliqu\u00e9es au D\u00e9veloppement et \u00e0 la Sant\u00e9 University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baulies","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, Instituto de Investigaciones Biom\u00e9dicas de Barcelona, Consejo Superior de Investigaciones Cient\u00edficas Liver Unit Hospital Cl\u00ednici Provincial, IDIBAPS and CIBERehd Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlem","family":"Bouhlel","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Physiology, Unit\u00e9 de Biologie et Anthropologie Mol\u00e9culaire Appliqu\u00e9es au D\u00e9veloppement et \u00e0 la Sant\u00e9 University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bejaoui","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Physiology, Unit\u00e9 de Biologie et Anthropologie Mol\u00e9culaire Appliqu\u00e9es au D\u00e9veloppement et \u00e0 la Sant\u00e9 University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Zaouali","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Physiology, Unit\u00e9 de Biologie et Anthropologie Mol\u00e9culaire Appliqu\u00e9es au D\u00e9veloppement et \u00e0 la Sant\u00e9 University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa","family":"Ben Mimouna","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources (LR11ES41), Institute of Biotechnology University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imed","family":"Messaoudi","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique, Biodiversit\u00e9 et Valorisation des Bioressources (LR11ES41), Institute of Biotechnology University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Fernandez\u2010Checa","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, Instituto de Investigaciones Biom\u00e9dicas de Barcelona, Consejo Superior de Investigaciones Cient\u00edficas Liver Unit Hospital Cl\u00ednici Provincial, IDIBAPS and CIBERehd Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Garc\u00eda Ruiz","sequence":"additional","affiliation":[{"name":"Department of Cell Death and Proliferation, Instituto de Investigaciones Biom\u00e9dicas de Barcelona, Consejo Superior de Investigaciones Cient\u00edficas Liver Unit Hospital Cl\u00ednici Provincial, IDIBAPS and CIBERehd Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassen","family":"Ben Abdennebi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Department of Physiology, Unit\u00e9 de Biologie et Anthropologie Mol\u00e9culaire Appliqu\u00e9es au D\u00e9veloppement et \u00e0 la Sant\u00e9 University of Monastir Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.02.040"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(99)00301-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80295-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.05.036"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28836"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20788"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"Bodiga V. 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