{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:12:12Z","timestamp":1791670332996,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100011512","name":"National Science Foundation, United Arab Emirates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      The zafirlukast has been reported to be anti\u2010inflammatory and widely used to alleviate the symptoms of asthma. However, its influence on insulin secretion in pancreatic \u03b2\u2010cells has not been investigated. Herein, we examined the effects of zafirlukast on insulin secretion and the potential underlying mechanisms. Among the cysteinyl leukotriene receptor 1 antagonists, zafirlukast, pranlukast, and montelukast, only zafirlukast enhanced insulin secretion in a concentration\u2010dependent manner in both low and high glucose conditions and elevated the level of [Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ]\n                      <jats:sub>i<\/jats:sub>\n                      , further activating Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \/calmodulin\u2010dependent protein kinase II (CaMKII), protein kinase B (AKT), and extracellular signal\u2010regulated kinase (ERK) signaling. These effects were nearly abolished by the L\u2010type Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channel antagonist nifedipine, while treatment with thapsigargin, a sarco\/endoplasmic reticulum Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ATPase inhibitor, did not have the same effect, suggesting that zafirlukast primarily induces the entry of extracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      rather than intracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      from the endoplasmic reticulum. Zafirlukast treatment resulting in a significant drop in glucose levels and increased insulin secretion in C57BL\/6J mice. These findings will contribute to an improved understanding of the side effects of zafirlukast and potential candidate for a therapeutic intervention in diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcp.26750","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T10:49:20Z","timestamp":1527158960000},"page":"8701-8710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Zafirlukast promotes insulin secretion by increasing calcium influx through L\u2010type calcium channels"],"prefix":"10.1002","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-9930","authenticated-orcid":false,"given":"Hyeon\u2010Jeong","family":"Hwang","sequence":"first","affiliation":[{"name":"School of Life Sciences Ulsan National Institute of Science and Technology Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung\u2010Su","family":"Park","sequence":"additional","affiliation":[{"name":"In Vivo Research Center Ulsan National Institute of Science and Technology Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jang Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"School of Life Sciences Ulsan National Institute of Science and Technology Ulsan Republic of Korea"},{"name":"Korea Mouse Phenotyping Center Ulsan National Institute of Science and Technology Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Cocco","sequence":"additional","affiliation":[{"name":"Cellular Signaling Laboratory, Department of Biomedical Sciences University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Jun","family":"Jang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Ulsan National Institute of Science and Technology Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-756X","authenticated-orcid":false,"given":"Pann\u2010Ghill","family":"Suh","sequence":"additional","affiliation":[{"name":"School of Life Sciences Ulsan National Institute of Science and Technology Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.5.1.64"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3400219"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3777"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb06974.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.5.9609014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202435109"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31822363a9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/isl.24166"},{"key":"e_1_2_8_12_1","first-page":"419","article-title":"Response of blood glucose to intravenous salicylate","volume":"10","author":"Gilgore S. 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