{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:52:49Z","timestamp":1793321569343,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors are therapeutic agents that have been used recently to reduce tubular absorption of glucose, leading to enhanced glycosuria, resulting in the reduction of blood glucose and improved diabetes control. Recent data suggest that SGLT2 inhibitors have antioxidant properties that may be key to the reduction in cardiovascular death found in clinical trials. Oxidative stress is involved in the development and progression of atherosclerosis, as well as underlying diabetes complications, and may result from either increased free\u2010radical production, a reduction in antioxidative capacity, or a combination of both. In this report, we have reviewed the recent evidence of the impact that SGLT2 inhibition may have on improved oxidative stress by either amelioration of free\u2010radical generation or potentiation of cellular antioxidative capacity, and its importance in the prevention of cardiovascular and diabetes complications.<\/jats:p>","DOI":"10.1002\/jcp.26760","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T06:31:19Z","timestamp":1542349879000},"page":"3231-3237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":160,"title":["Sodium\u2013glucose cotransporter inhibitors and oxidative stress: An update"],"prefix":"10.1002","volume":"234","author":[{"given":"Habib","family":"Yaribeygi","sequence":"first","affiliation":[{"name":"Neurosciences Research Center, Baqiyatallah University of Medical Sciences Tehran Iran"},{"name":"Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-7257","authenticated-orcid":false,"given":"Stephen L.","family":"Atkin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine Qatar Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3917","authenticated-orcid":false,"given":"Alexandra E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Anti\u2010Doping Laboratory Qatar, Life Sciences Research Division Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0100"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16463-6"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4765"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.02.017"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diaclin.32.1.4"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3180"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005081"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-001007"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.15.1610"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.652859"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.170"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.011"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72227"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.140210"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108994"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093660.86242.BB"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0489-z"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00422.2013"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1472"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2200"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.4331\/wjbc.v6.i3.209"},{"key":"e_1_2_8_1_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990507"},{"issue":"3","key":"e_1_2_8_1_24_1","first-page":"191","article-title":"Tofogliflozin, a highly selective inhibitor of SGLT2 blocks proinflammatory and proapoptotic effects of glucose overload on proximal tubular cells partly by suppressing oxidative stress generation","volume":"48","author":"Ishibashi Y.","year":"2016","journal-title":"Hormone and Metabolic Research"},{"key":"e_1_2_8_1_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2016.1251711"},{"key":"e_1_2_8_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-014-0089-4"},{"key":"e_1_2_8_1_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18051083"},{"key":"e_1_2_8_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.10.010"},{"key":"e_1_2_8_1_29_1","doi-asserted-by":"publisher","DOI":"10.5607\/en.2015.24.4.325"},{"key":"e_1_2_8_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2017.10.006"},{"key":"e_1_2_8_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2407"},{"key":"e_1_2_8_1_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5205"},{"key":"e_1_2_8_1_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.144154"},{"key":"e_1_2_8_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.07.102"},{"key":"e_1_2_8_1_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/507278"},{"key":"e_1_2_8_1_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq396"},{"key":"e_1_2_8_1_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890701854702"},{"key":"e_1_2_8_1_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_2_8_1_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom5010194"},{"key":"e_1_2_8_1_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112394"},{"key":"e_1_2_8_1_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/542042"},{"key":"e_1_2_8_1_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu6010355"},{"key":"e_1_2_8_1_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-017-0320-1"},{"key":"e_1_2_8_1_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1380"},{"key":"e_1_2_8_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.08.005"},{"key":"e_1_2_8_1_46_1","doi-asserted-by":"publisher","DOI":"10.14740\/jocmr3011w"},{"key":"e_1_2_8_1_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1875"},{"key":"e_1_2_8_1_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.103226"},{"key":"e_1_2_8_1_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32832923c3"},{"key":"e_1_2_8_1_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.600"},{"key":"e_1_2_8_1_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0165703"},{"key":"e_1_2_8_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"e_1_2_8_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.03.005"},{"key":"e_1_2_8_1_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000084"},{"key":"e_1_2_8_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.06.009"},{"key":"e_1_2_8_1_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-017-0012-0"},{"key":"e_1_2_8_1_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0371-7"},{"key":"e_1_2_8_1_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.05.014"},{"key":"e_1_2_8_1_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs260"},{"key":"e_1_2_8_1_60_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i3.456"},{"key":"e_1_2_8_1_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.954109"},{"key":"e_1_2_8_1_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100777"},{"key":"e_1_2_8_1_63_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2014.005"},{"key":"e_1_2_8_1_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200503000-00007"},{"key":"e_1_2_8_1_65_1","doi-asserted-by":"publisher","DOI":"10.5830\/CVJA-2013-046"},{"key":"e_1_2_8_1_66_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00809.2010"},{"key":"e_1_2_8_1_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4157-3"},{"key":"e_1_2_8_1_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4157-3"},{"key":"e_1_2_8_1_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.779520"},{"key":"e_1_2_8_1_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-012-0433-2"},{"key":"e_1_2_8_1_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12187"},{"key":"e_1_2_8_1_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00052-8"},{"key":"e_1_2_8_1_73_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/752387"},{"key":"e_1_2_8_1_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-4376-5_16"},{"key":"e_1_2_8_1_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26450"},{"key":"e_1_2_8_1_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.077"},{"key":"e_1_2_8_1_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504720"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.26760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.26760","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.26760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:29:29Z","timestamp":1747996169000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.26760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/jcp.26760"],"URL":"https:\/\/doi.org\/10.1002\/jcp.26760","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"2018-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}