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EGFL7 plays a vital role in controlling vascular angiogenesis during embryogenesis, organogenesis, and maintaining skeletal homeostasis. It regulates cellular functions by mediating the main signaling pathways (Notch, integrin) and EGF receptor cascades. Accumulating evidence suggests that Egfl7 plays a crucial role in cancer biology by modulating tumor angiogenesis, metastasis, and invasion. Dysregulation of\n                    <jats:italic>Egfl7<\/jats:italic>\n                    has been frequently found in several types of cancers, such as malignant glioma, colorectal carcinoma, oral and oesophageal cancers, gastric cancer, hepatocellular carcinoma, pancreatic cancer, breast cancer, lung cancer, osteosarcoma, and acute myeloid leukemia. In addition, altered expression of miR\u2010126, a microRNA associated with\n                    <jats:italic>Egfl7<\/jats:italic>\n                    , was found to play an important role in oncogenesis. More recently, our study has shown that EGFL7 is expressed in both the osteoclast and osteoblast lineages and promotes endothelial cell activities via extracellular signal\u2010regulated kinase (ERK), signal transducer and activator of transcription 3 (STAT3), and integrin signaling cascades, indicative of its angiogenic regulation in the bone microenvironment. Thus, understanding the role of EGFL7 may provide novel insights into the development of improved diagnostics and therapeutic treatment for cancers and skeletal pathological disorders, such as ischemic osteonecrosis and bone fracture healing.\n                  <\/jats:p>","DOI":"10.1002\/jcp.26792","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T01:50:37Z","timestamp":1529459437000},"page":"8526-8537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["EGFL7: Master regulator of cancer pathogenesis, angiogenesis and an emerging mediator of bone homeostasis"],"prefix":"10.1002","volume":"233","author":[{"given":"Guoju","family":"Hong","sequence":"first","affiliation":[{"name":"National Key Discipline and Orthopedic Laboratory Guangzhou University of Chinese Medicine  Guangzhou Guangdong China"},{"name":"Division of Regenerative Medicine, School of Biomedical Sciences, The 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