{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:21:20Z","timestamp":1790554880253,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Cancer cachexia is a complex disorder that is driven by inflammation and metabolic imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer cachexia, is an essential metabolic and secretory organ consisting of both white adipose tissue (WAT) and brown adipose tissue. Its secretory products, including adipokines and cytokines, affect a wide variety of central and peripheral organs, such as the skeletal muscle, brain, pancreas, and liver. Therefore, a combination of metabolic alterations, and systemic inflammation dysregulation of both anti\u2010inflammatory and proinflammatory modulators contribute toward adipose tissue wasting in cancer cachexia. Growing evidence suggests that, during cancer cachexia, WAT undergoes a browning process, resulting in increased lipid mobilization and energy expenditure. In this review, we have summarized the characteristics of cancer cachexia and WAT browning. Furthermore, this review describes how adipose tissue becomes inflamed in cancer, shedding light on the combinatorial action of multiple secreted macromolecules, cytokines, hormones, and tumor mediators on adipose tissue dysfunction. We also highlight the inflammatory responses, energy utilization defects, and molecular mechanisms underlying the WAT dysfunction and browning in cancer cachexia. Further, the actual mechanisms behind the loss of adipose tissue are unknown, but have been attributed to increased adipocyte lipolysis, systemic inflammation, and apoptosis or reduced lipogenesis. The understanding of adipose tissue dysfunction in cancer cachexia will hopefully promote the development of new therapeutic approaches to prevent or treat this wasting syndrome.<\/jats:p>","DOI":"10.1002\/jcp.26811","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:55:06Z","timestamp":1533610506000},"page":"13-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Adipose tissue dysfunction in cancer cachexia"],"prefix":"10.1002","volume":"234","author":[{"given":"Sahar I.","family":"Daas","sequence":"first","affiliation":[{"name":"Department of Biomedical and Biological Sciences Hamad Bin Khalifa University  Doha Qatar"},{"name":"Reseach Branch Sidra Medicine  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balsam R.","family":"Rizeq","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences College of Arts and Sciences, Qatar University  Doha Qatar"},{"name":"Biomedical Research Center, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-1038","authenticated-orcid":false,"given":"Gheyath K.","family":"Nasrallah","sequence":"additional","affiliation":[{"name":"Biomedical Research Center, Qatar University  Doha Qatar"},{"name":"Department of Biomedical Science College of Health Sciences, Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,4]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.06.006"},{"key":"e_1_2_10_1_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-015-0762-z"},{"key":"e_1_2_10_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3829"},{"key":"e_1_2_10_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2012.04.011"},{"key":"e_1_2_10_1_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/182872"},{"key":"e_1_2_10_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.03.002"},{"issue":"18","key":"e_1_2_10_1_8_1","first-page":"3727","article-title":"Is irisin a decisive protein in cancer cachexia and death of cancer cells?","volume":"20","author":"Aydin S.","year":"2016","journal-title":"European Review for Medical and Pharmacological Sciences"},{"issue":"1","key":"e_1_2_10_1_9_1","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard J.\u2010P.","year":"2006","journal-title":"European Cytokine Network"},{"key":"e_1_2_10_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.10.008"},{"key":"e_1_2_10_1_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168945"},{"key":"e_1_2_10_1_12_1","first-page":"2015","article-title":"Differential effects of interleukin\u20106 and activin A in the development of cancer\u2010associated cachexia","volume":"3152","author":"Chen J. 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