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The main pathological manifestation of CAD is myocardial injury due to ischemia\u2013reperfusion (I\u2013R). Currently, no efficacious treatment of protecting the heart against myocardial I\u2013R exists. Hence, it is necessary to discover or develop novel strategies to prevent myocardial\u2010reperfusion injury to improve clinical outcomes in patients with CAD. A large body of experimental evidence supports cardioprotective properties of curcumin and the ability of this phytochemical to modify some cardiovascular risk factors. However, the detailed effects of curcumin in myocardial I\u2013R injury are still unclear and there is a lack of evidence concerning which curcumin regimen may be ideal for myocardial I\u2013R injury. This paper presents a brief review of the pathophysiology of myocardial I\u2013R injury and the mechanisms of action of curcumin in reducing myocardial I\u2013R injury.<\/jats:p>","DOI":"10.1002\/jcp.26848","type":"journal-article","created":{"date-parts":[[2018,7,3]],"date-time":"2018-07-03T08:23:35Z","timestamp":1530606215000},"page":"214-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["The protective role of curcumin in myocardial ischemia\u2013reperfusion injury"],"prefix":"10.1002","volume":"234","author":[{"given":"Amin","family":"Mokhtari\u2010Zaer","sequence":"first","affiliation":[{"name":"Department of Physiology School of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Marefati","sequence":"additional","affiliation":[{"name":"Department of Physiology School of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-7257","authenticated-orcid":false,"given":"Stephen L.","family":"Atkin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine Qatar  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-3917","authenticated-orcid":false,"given":"Alexandra E.","family":"Butler","sequence":"additional","affiliation":[{"name":"Life Sciences Research Division Anti\u2010Doping Laboratory Qatar  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Neurogenic Inflammation Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,3]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25778"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.08.008"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.09.013"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00793-9"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.4.1620"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5698931"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4825"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303584"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199919"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.09.006"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-012-0263-7"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.12.013"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2507"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.06.013"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.014340"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12012-011-9128-9"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.187427"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3322"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.05.020"},{"key":"e_1_2_6_1_21_1","first-page":"68","article-title":"Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog","volume":"70","author":"Jennings R. 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