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Recently, miR\u2010214 emerged as a critical regulator of musculoskeletal metabolism. Specifically, miR\u2010214 can mediate skeletal muscle myogenesis and vascular smooth muscle cell proliferation, migration, and differentiation. MiR\u2010214 also modulates osteoblast function by targeting specific molecular pathways and the expression of various osteoblast\u2010related genes; promotes osteoclast activity by targeting phosphatase and tensin homolog (Pten); and mediates osteoclast\u2010osteoblast intercellular crosstalk via an exosomal miRNA paracrine mechanism. Importantly, dysregulation in miR\u2010214 expression is associated with pathological bone conditions such as osteoporosis, osteosarcoma, multiple myeloma, and osteolytic bone metastasis of breast cancer. This review discusses the cellular targets of miR\u2010214 in bone, the molecular mechanisms governing the activities of miR\u2010214 in the musculoskeletal system, and the putative role of miR\u2010214 in skeletal diseases. Understanding the biology of miR\u2010214 could potentially lead to the development of miR\u2010214 as a possible biomarker and a therapeutic target for musculoskeletal diseases.<\/jats:p>","DOI":"10.1002\/jcp.26856","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:41:15Z","timestamp":1533609675000},"page":"231-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["MiR\u2010214 is an important regulator of the musculoskeletal metabolism and disease"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-5374","authenticated-orcid":false,"given":"Youqiang","family":"Sun","sequence":"first","affiliation":[{"name":"The Department of Orthopedics, First Affiliated Hospital Guangzhou University of Chinese Medicine Guangzhou Guangdong China"},{"name":"Division of Pathology and Laboratory Medicine, School of Biomedical Sciences, The University of 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