{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:17Z","timestamp":1786978037899,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,5]],"date-time":"2018-08-05T00:00:00Z","timestamp":1533427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,5]],"date-time":"2018-08-05T00:00:00Z","timestamp":1533427200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Hyperoxia (&gt;90% oxygen) is commonly implemented in mechanically ventilated patients. Reports suggest that hyperoxia is directly associated with in\u2010hospital mortality in ventilated patients. Certain studies also show that mortality in women undergoing mechanical ventilation is significantly higher than that in men. Additionally, females are predisposed to certain cardiac electrophysiological risks, including QTc prolongation. In this study, we assessed the impact of hyperoxia in male and female mice (C57BL\/6J) at age 8\u201310 weeks. On completion of either hyperoxia or normoxia exposures, physical, hemodynamic, biochemical, functional, electrophysiological, and molecular assessments were conducted. Hyperoxia\u2010exposed mice lost a significant amount of body mass, compared with normoxia controls, in both sexes. However, while both genders developed brady\u2010arrhythmia after hyperoxia exposure, female mice exhibited significantly reduced heart rates compared with males, with significantly elevated RR intervals. Additionally, 50% mortality was observed in females, whereas no mortality was reported in males. Furthermore, unlike in male mice, we observed no hypertrophy upon hyperoxia exposure in female mice. We reported that both hyperoxia\u2010treated male and female mice exhibit significant hyperdynamic left ventricular ejection fraction, which is marked by % ejection fraction\u2009&gt;\u200970 compared with the normoxia controls. We also noted significant reductions in stroke volume and cardiac output in both mice with hyperoxia. Surface ECG also demonstrated that hyperoxia exposure significantly augments RR, PR, QRS, QTc, and JT intervals in both sexes. Molecular analysis of left ventricular tissue demonstrated dysregulation of potassium ion channels in hyperoxia\u2010treated males and females. In summary, we determined that sex differences are present with 72\u2009hr hyperoxia exposure.<\/jats:p>","DOI":"10.1002\/jcp.27010","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:59:59Z","timestamp":1533610799000},"page":"1491-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sex differences in murine cardiac pathophysiology with hyperoxia exposure"],"prefix":"10.1002","volume":"234","author":[{"given":"Jennifer L.","family":"Rodgers","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, University of South Florida Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia E.","family":"Rodgers","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, University of South Florida Tampa 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