{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:48:11Z","timestamp":1792442891933,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL115265"],"award-info":[{"award-number":["R01 HL115265"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL089405"],"award-info":[{"award-number":["R01 HL089405"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    Irisin, a newly identified hormone and cardiokine, is critical for modulating body metabolism. New evidence indicates that irisin protects the heart against myocardial ischemic injury. However, whether irisin enhances cardiac progenitor cell (CPC)\u2010induced cardiac repair remains unknown. This study examines the effect of irisin on\u00a0CPC\u2010induced cardiac repair when these cells are introduced into the infarcted myocardium. Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPC stable cells were isolated from mouse embryonic stem cells. Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPCs (0.5\u2009\u00d7\u200910\n                    <jats:sup>6<\/jats:sup>\n                    ) were reintroduced into the infarcted myocardium using PEGlylated fibrin delivery. The mouse myocardial infarction model was created by permanent ligation of the left anterior descending (LAD) artery. Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPCs were pretreated with irisin at a concentration of 5\u2009ng\/ml in vitro for 24\u2009hr before transplantation. Myocardial functions were evaluated by echocardiographic measurement. Eight weeks after engraftment, Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPCs improved ventricular function as evident by an increase in ejection fraction and fractional shortening. These findings are concomitant with the suppression of cardiac hypertrophy and attenuation of myocardial interstitial fibrosis. Transplantation of Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPCs promoted cardiac regeneration and neovascularization, which were increased with the pretreatment of Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPCs with irisin. Furthermore, irisin treatment promoted myocyte proliferation as indicated by proliferative markers Ki67 and phosphorylated histone 3 and decreased apoptosis. Additionally, irisin resulted in a marked reduction of histone deacetylase 4 and increased p38 acetylation in cultured CPCs. These results indicate that irisin promoted Nkx2.5\n                    <jats:sup>+<\/jats:sup>\n                    CPC\u2010induced cardiac regeneration and functional improvement and that irisin serves as a novel therapeutic approach for stem cells in cardiac repair.\n                  <\/jats:p>","DOI":"10.1002\/jcp.27037","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T07:41:41Z","timestamp":1535787701000},"page":"1671-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Irisin promotes cardiac progenitor cell\u2010induced myocardial repair and functional improvement in infarcted heart"],"prefix":"10.1002","volume":"234","author":[{"given":"Yu Tina","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center Boston University School of Medicine Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center Boston University School of Medicine Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine Rhode Island Hospital, Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center Boston University School of Medicine Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine Luoyang Central Hospital, Zhengzhou University Luoyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangjian","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja M.","family":"Dubielecka","sequence":"additional","affiliation":[{"name":"Department of Medicine Rhode Island Hospital, Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shougang","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Medicine Rhode Island Hospital, Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Rhode Island Hospital, Brown University Providence Rhode Island"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. Eugene","family":"Chin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences\u2010Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-0275","authenticated-orcid":false,"given":"Ting C.","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Roger Williams Medical Center Boston University School of Medicine Providence Rhode 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