{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:05:59Z","timestamp":1784106359485,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,4]],"date-time":"2018-08-04T00:00:00Z","timestamp":1533340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Natural Science Research Key Projects of Anhui Higher Education Institutions","award":["KJ2018A0462"],"award-info":[{"award-number":["KJ2018A0462"]}]},{"name":"Anhui Higher Institutions","award":["KJ2018A0462"],"award-info":[{"award-number":["KJ2018A0462"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>\n                    To explore the protective effect of exercise training on the injury of myocardium tissues induced by streptozotocin (STZ) in diabetic rats and the relationship with endoplasmic reticulum stress (ERS), the male sprague\u2010dawley (SD) rats were fed with high\u2010fat and high\u2010sugar diet for 4 weeks, followed by intraperitoneal injection of\u00a0STZ, 40\u2009mg\/kg, to establish a diabetes model, and then 10 rats were randomly selected as diabetes mellitus (DM) controls and 20 eligible diabetic rats were randomized into two groups: low\u2010intensity exercise training (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910) and high\u2010intensity exercise training (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910). After 12 weeks of exercise training, rats were killed and serum samples were used to determine cardiac troponin\u2010I (cTn\u2010I). Myocardial tissues were sampled for morphological analysis to detect myocardial cell apoptosis, and to analyze protein expression of glucose\u2010regulated protein 78 (GRP78), C\/EBP homologous protein (CHOP), and caspase\u201012. Different intensities (low and high) significantly reduced serum cTn\u2010I levels compared with the DCM group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and significantly reduced the percentage of apoptotic myocardial cells and improved the parameters of cardiac function. Hematoxylin and eosin and Masson staining indicated that exercise training could attenuate myocardial apoptosis. Additionally, exercise training significantly reduced GRP78, CHOP, and cleaved caspase\u201012 protein expression in an intensity\u2010dependent manner. These findings suggest that exercise appeared to ameliorate diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress\u2010induced apoptosis in diabetic rats.\n                  <\/jats:p>","DOI":"10.1002\/jcp.27038","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T02:42:09Z","timestamp":1533609729000},"page":"1682-1688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Exercise protects against diabetic cardiomyopathy by the inhibition of the endoplasmic reticulum stress pathway in rats"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-9117","authenticated-orcid":false,"given":"Wang","family":"Chengji","sequence":"first","affiliation":[{"name":"College of Physical Education, Chaohu University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xianjin","sequence":"additional","affiliation":[{"name":"College of Physical Education, Chaohu University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,4]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35014014"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407704-1.00005-1"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3171-6"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.01.027"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1310265"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10239"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/11535930-000000000-00000"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.18.011402.160624"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-124001"},{"issue":"7","key":"e_1_2_9_1_11_1","first-page":"5","article-title":"Regulation by exercise of skeletal muscle content of mitochondria and GLUT4","volume":"59","author":"Holloszy J. 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