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In the current study, our aim was to explore the possible effects Fos\u2010like antigen\u20101 (FOSL1) had on the silencing regarding OS cell proliferation, invasion, and migration through the activation of the extracellular\u2010signal\u2010regulated kinase (ERK)\/activator protein\u20101 (AP\u20101) signaling pathway. After the collection of OS on top of already having the adjacent normal tissue samples, the protein positive expression rate of FOSL1 was then measured by implementing the use of immunohistochemistry and discovered that FOSL1 was robustly expressed in OS. Later, to better grasp the impact FOSL1 projects on OS and its underlying mechanism, we determined the OS related genes as well as the ERK\/AP\u20101 signaling pathway related genes expression by using a reverse\u2010transcription quantitative polymerase chain reaction and western blot assay techniques. The results of the aforementioned two experiments revealed that the FOSL1 depletion had downregulated the expression of OS related genes by simultaneously downregulating the ERK\/AP\u20101 signaling pathway. Moreover, cell proliferation, cycle, apoptosis, invasion, and migration of FOS1 were all tested by using a cell counting kit\u20108 assay, flow cytometry, Transwell assay, and scratch test, and these results presented that silencing of the FOSL1 gene inhibited OS cell proliferation, invasion, and migration. Our findings revealed a novel mechanism by which FOSL1 depletion played a significantly negative role in the OS progression through the regulation of the\u00a0ERK\/AP\u20101 signaling pathway. Functional suppression of FOSL1 might be a future therapeutic strategy regarding OS.<\/jats:p>","DOI":"10.1002\/jcp.27048","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T15:01:09Z","timestamp":1543071669000},"page":"3598-3612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<i>Retracted<\/i>: Effects of FOSL1 silencing on osteosarcoma cell proliferation, invasion and migration through the ERK\/AP\u20101 signaling pathway"],"prefix":"10.1002","volume":"234","author":[{"given":"Yu","family":"Han","sequence":"first","affiliation":[{"name":"Joint Surgery Department No.1 Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Joint Surgery Department No.1 Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifu","family":"Sun","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-8562","authenticated-orcid":false,"given":"Yutong","family":"Sui","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory for Molecular Biology of Special Economic Animals Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Joint Surgery Department No.1 Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,23]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3463"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.082008"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10120"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00303"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/959248"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931115)72:10<2979::AID-CNCR2820721020>3.0.CO;2-X"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.05.007"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2490"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0036"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600282"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.April.10.26"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26366"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070516"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cam.25894"},{"issue":"10","key":"e_1_2_7_1_16_1","first-page":"705","article-title":"Osteosarcoma: A review of diagnosis, management, and treatment strategies","volume":"8","author":"Geller D. 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