{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:17:48Z","timestamp":1787505468337,"version":"build-2736575974"},"reference-count":117,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T00:00:00Z","timestamp":1534809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2015A030310478"],"award-info":[{"award-number":["2015A030310478"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030313703"],"award-info":[{"award-number":["2017A030313703"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400190"],"award-info":[{"award-number":["81400190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:p>Acute myocardial infarction is a major cause of death worldwide. The most important therapy for limiting ischemic injury and infarct size is timely and efficient myocardial reperfusion treatment, which may instead induce cardiomyocyte necrosis due to myocardial ischemia\u2013reperfusion (I\/R) injury. Heat shock protein 70 (HSP70), a stress\u2010inducible protein, is overexpressed during myocardial I\/R. The induced HSP70 is shown to regulate several intracellular proteins (e.g., transcription factors, enzymes, and apoptosis\u2010related proteins) and signaling pathways (e.g., c\u2010Jun N\u2010terminal kinase pathway and extracellular\u2010signal\u2010regulated kinase 1\/2 pathway), forming a complicated network that contributes to reducing reactive oxygen species accumulation, improving calcium homeostasis, inhibiting cellular apoptosis, thereby enhancing the stress adaption of myocardium to I\/R injury. In addition, the extracellular HSP70, which is released from injured cardiomyocytes during I\/R, acts as a proinflammatory mediator that results in cell death, while the intracellular HSP70 exerts antiinflammatory effects by suppressing proinflammatory signaling pathways. Notably, HSP70 is induced and contributes to the cardioprotection in several types of preconditioning and postconditioning. Meanwhile, it is shown that the cardioprotective effectiveness of preconditioning\u2010induced HSP70 (e.g., hyperthermia preconditioning\u2010induced HSP70) can be impaired by certain pathological conditions, such as hyperlipidemia and hyperglycemia. Thus, we highlight the widespread cardioprotective involvement of HSP70 in preconditioning and postconditioning and elucidate how HSP70\u2010mediated cardioprotection is impaired in these pathological conditions. Furthermore, several therapeutic potentials of HSP70 against myocardial I\/R injury and potential directions for future studies are also provided in this review.<\/jats:p>","DOI":"10.1002\/jcp.27110","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T12:12:48Z","timestamp":1534939968000},"page":"1190-1207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Heat shock protein 70: A promising therapeutic target for myocardial ischemia\u2013reperfusion injury"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5958-7326","authenticated-orcid":false,"given":"Yan\u2010Jun","family":"Song","sequence":"first","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Sino\u2010Japanese Cooperation Platform for Translational Research in Heart Failure, Laboratory of Heart Center, Department of Cardiology, Heart Center, Zhujiang Hospital Southern Medical University Guangzhou China"},{"name":"School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-8818","authenticated-orcid":false,"given":"Chong\u2010Bin","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Sino\u2010Japanese Cooperation Platform for Translational Research in Heart Failure, Laboratory of Heart Center, Department of Cardiology, Heart Center, Zhujiang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-2573","authenticated-orcid":false,"given":"Xian\u2010Bao","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Sino\u2010Japanese Cooperation Platform for Translational Research in Heart Failure, Laboratory of Heart Center, Department of Cardiology, Heart Center, Zhujiang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"e_1_2_11_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4113"},{"key":"e_1_2_11_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.663"},{"key":"e_1_2_11_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw216"},{"key":"e_1_2_11_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.11.159"},{"key":"e_1_2_11_1_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00269.2006"},{"key":"e_1_2_11_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80928-9"},{"key":"e_1_2_11_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.024"},{"key":"e_1_2_11_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.153"},{"key":"e_1_2_11_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy014"},{"key":"e_1_2_11_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2016.03.021"},{"key":"e_1_2_11_1_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4457"},{"key":"e_1_2_11_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1568-z"},{"key":"e_1_2_11_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0164-1"},{"key":"e_1_2_11_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.12.010"},{"key":"e_1_2_11_1_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6377"},{"key":"e_1_2_11_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.05.039"},{"key":"e_1_2_11_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13302"},{"key":"e_1_2_11_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.003"},{"key":"e_1_2_11_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338149"},{"key":"e_1_2_11_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0602.103617"},{"key":"e_1_2_11_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.09.171"},{"key":"e_1_2_11_1_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.077305"},{"key":"e_1_2_11_1_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073537"},{"key":"e_1_2_11_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1571"},{"key":"e_1_2_11_1_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/346623a0"},{"key":"e_1_2_11_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy039"},{"key":"e_1_2_11_1_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006632200"},{"key":"e_1_2_11_1_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481755"},{"key":"e_1_2_11_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-015-0589-9"},{"key":"e_1_2_11_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21461"},{"key":"e_1_2_11_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2008.02.040"},{"key":"e_1_2_11_1_33_1","doi-asserted-by":"crossref","unstructured":"Guo S. Gao C. Xiao W. Zhang J. Qu Y. Li J. &Ye F.(2018).Matrine protects cardiomyocytes from ischemia\/reperfusion injury by regulating HSP70 expression via activation of the JAK2\/STAT3 pathway. Shock https:\/\/doi.org\/10.1097\/SHK.0000000000001108. [Epub ahead of print].","DOI":"10.1097\/SHK.0000000000001108"},{"key":"e_1_2_11_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.03.031"},{"key":"e_1_2_11_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn037"},{"key":"e_1_2_11_1_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00596.2002"},{"key":"e_1_2_11_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.01.017"},{"key":"e_1_2_11_1_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.85"},{"key":"e_1_2_11_1_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.305348"},{"key":"e_1_2_11_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.10.031"},{"key":"e_1_2_11_1_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00362.2005"},{"key":"e_1_2_11_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.10.001"},{"key":"e_1_2_11_1_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-013-0425-z"},{"key":"e_1_2_11_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2015.12.007"},{"key":"e_1_2_11_1_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu006"},{"key":"e_1_2_11_1_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07510.x"},{"key":"e_1_2_11_1_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu027"},{"key":"e_1_2_11_1_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01144.2004"},{"key":"e_1_2_11_1_49_1","doi-asserted-by":"publisher","DOI":"10.1385\/CT:5:2:183"},{"key":"e_1_2_11_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.08.045"},{"key":"e_1_2_11_1_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.598409"},{"key":"e_1_2_11_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.09.023"},{"key":"e_1_2_11_1_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.07.008"},{"key":"e_1_2_11_1_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00201.2006"},{"key":"e_1_2_11_1_55_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00675.2007"},{"key":"e_1_2_11_1_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-012-0228-5"},{"key":"e_1_2_11_1_57_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.067926"},{"key":"e_1_2_11_1_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00145.2005"},{"key":"e_1_2_11_1_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-016-0039-8"},{"issue":"12","key":"e_1_2_11_1_60_1","first-page":"2913","article-title":"Fas\/FasL induces myocardial cell apoptosis in myocardial ischemia\u2010reperfusion rat model","volume":"21","author":"Liu X. M.","year":"2017","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_11_1_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-010-0236-4"},{"key":"e_1_2_11_1_62_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203715666140331113057"},{"key":"e_1_2_11_1_63_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0194"},{"key":"e_1_2_11_1_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.10.011"},{"key":"e_1_2_11_1_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00632-2"},{"key":"e_1_2_11_1_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187095"},{"key":"e_1_2_11_1_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0274-x"},{"key":"e_1_2_11_1_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-017-0527-5"},{"key":"e_1_2_11_1_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.9.2185"},{"key":"e_1_2_11_1_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.7.934"},{"key":"e_1_2_11_1_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-007-0645-4"},{"key":"e_1_2_11_1_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12491"},{"key":"e_1_2_11_1_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.210914"},{"issue":"6","key":"e_1_2_11_1_74_1","first-page":"483","article-title":"Kinetics of plasma heat shock protein HSP\u201070 release in coronary artery surgery: On\u2010pump versus off\u2010pump","volume":"61","author":"Pizon M. T.","year":"2006","journal-title":"Minerva Chirurgica"},{"key":"e_1_2_11_1_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-003-1288-0"},{"key":"e_1_2_11_1_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02172188"},{"key":"e_1_2_11_1_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0662-x"},{"key":"e_1_2_11_1_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2006.03.004"},{"key":"e_1_2_11_1_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000170"},{"key":"e_1_2_11_1_80_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2002.122305"},{"key":"e_1_2_11_1_81_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00493.2007"},{"key":"e_1_2_11_1_82_1","doi-asserted-by":"publisher","DOI":"10.2337\/db05-0266"},{"key":"e_1_2_11_1_83_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160413142028"},{"key":"e_1_2_11_1_84_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00152.2018"},{"key":"e_1_2_11_1_85_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00895.2005"},{"key":"e_1_2_11_1_86_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000779"},{"issue":"12","key":"e_1_2_11_1_87_1","first-page":"I270","article-title":"Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia\u2010reperfusion injury, associated with mitochondrial protection and apoptosis reduction","volume":"106","author":"Suzuki K.","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_11_1_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr254"},{"key":"e_1_2_11_1_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.762"},{"key":"e_1_2_11_1_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00748.2015"},{"key":"e_1_2_11_1_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2010.10.018"},{"key":"e_1_2_11_1_92_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1052"},{"key":"e_1_2_11_1_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.221796"},{"key":"e_1_2_11_1_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.07.001"},{"key":"e_1_2_11_1_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.06.031"},{"key":"e_1_2_11_1_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.10.046"},{"key":"e_1_2_11_1_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.026"},{"key":"e_1_2_11_1_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248411415270"},{"key":"e_1_2_11_1_99_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488047"},{"issue":"12","key":"e_1_2_11_1_100_1","first-page":"2603","article-title":"Later phase cardioprotection of ischemic post\u2010conditioning against ischemia\/reperfusion injury depends on iNOS and PI3K\u2010Akt pathway","volume":"7","author":"Wang G.","year":"2015","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_1_101_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093536"},{"key":"e_1_2_11_1_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.02.003"},{"key":"e_1_2_11_1_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.03.011"},{"key":"e_1_2_11_1_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.06.015"},{"key":"e_1_2_11_1_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-012-1386-8"},{"key":"e_1_2_11_1_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(03)00133-0"},{"key":"e_1_2_11_1_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-014-0089-9"},{"key":"e_1_2_11_1_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-010-0242-6"},{"key":"e_1_2_11_1_109_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"e_1_2_11_1_110_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.193250"},{"key":"e_1_2_11_1_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-017-1355-5"},{"key":"e_1_2_11_1_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2016.05.020"},{"key":"e_1_2_11_1_113_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00416.2003"},{"key":"e_1_2_11_1_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-010-0180-3"},{"key":"e_1_2_11_1_115_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6437467"},{"key":"e_1_2_11_1_116_1","doi-asserted-by":"publisher","DOI":"10.1379\/CSC-231R.1"},{"issue":"2","key":"e_1_2_11_1_117_1","first-page":"386","article-title":"Geranylgeranylacetone attenuates myocardium ischemic\/reperfusion injury through HSP70 and Akt\/GSK\u20103beta\/eNOS pathway. American journal of translational research","volume":"9","author":"Zhou C.","year":"2017","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_1_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.1.H40"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:31:17Z","timestamp":1777699877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,21]]},"references-count":117,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/jcp.27110"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27110","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,21]]},"assertion":[{"value":"2018-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}