{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T20:41:10Z","timestamp":1778704870617,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Science and Technology Public Relations Project of Henan Provincial Science and Technology Department","award":["162102310131"],"award-info":[{"award-number":["162102310131"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian cancer (OC) is a lethal gynecologic tumor, which brings its mortality to the head. <jats:italic>CXCL12<\/jats:italic> and its receptor chemokine receptor 4 (\n<jats:italic>CXCR4<\/jats:italic>) have been found to be highly expressed in OC and contribute to the disease progression by affecting tumor cell proliferation and invasion. Here, in this study, we aim to explore whether the blockade of CXCL12\u2013CXCR4 axis with AMD3100 (a selective <jats:italic>CXCR4<\/jats:italic> antagonist) has effects on the progression of OC. On the basis of the gene expression omnibus database of OC gene expression chips, the OC differentially expressed genes were screened by microarray analysis. OC (nonmetastatic and metastatic) and normal ovarian tissues were collected to determine the expressions of <jats:italic>CXCL12<\/jats:italic> and <jats:italic>CXCR4<\/jats:italic>. A series of AMD3100, shRNA against <jats:italic>CXCR4<\/jats:italic>, and pCNS\u2010CXCR4 were introduced to treat CAOV3 cells with the highest <jats:italic>CXCR4<\/jats:italic> was assessed. Cell viability, apoptosis, migration, and invasion were all evaluated. The microarray analysis screened out the differential expression of CXCL12\u2013CXCR4 in OC. <jats:italic>CXCL12<\/jats:italic> and <jats:italic>CXCR4<\/jats:italic> expressions were increased in OC tissues, particularly in the metastatic OC tissues. Downregulation of <jats:italic>CXCR4<\/jats:italic> by AMD3100 or shRNA was observed to have a critical role in inhibiting cell proliferation, migration, and invasion of the CAOV3 OC cell line while promoting cell apoptosis. Overexpressed <jats:italic>CXCR4<\/jats:italic> brought significantly promoting effects on the proliferation and invasiveness of OC cells. These results reinforce that the blockade of CXCL12\u2013CXCR4 axis with AMD3100 inhibits the growth of OC cells. The antitumor role of the inhibition of CXCL12\u2013CXCR4 axis offers a preclinical validation of CXCL12\u2013CXCR4 axis as a therapeutic target in OC.<\/jats:p>","DOI":"10.1002\/jcp.27163","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T14:16:48Z","timestamp":1536329808000},"page":"3897-3909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["<i>Retracted<\/i>: Role of CXCL12\u2013CXCR4 axis in ovarian cancer metastasis and CXCL12\u2013CXCR4 blockade with AMD3100 suppresses tumor cell migration and invasion in vitro"],"prefix":"10.1002","volume":"234","author":[{"given":"Yan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Chen","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-9153","authenticated-orcid":false,"given":"Yan\u2010Nan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The Third Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-293"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2644"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0501-9"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557054867075"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.08.009"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.05.005"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.12324"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0415-y"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1473"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg405"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400201"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4974-5"},{"issue":"5","key":"e_1_2_7_1_14_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3727\/096504015X14343704124430","article-title":"CXCL12\u2010CXCR4 axis promotes proliferation, migration, invasion, and metastasis of ovarian cancer","volume":"22","author":"Guo Q.","year":"2014","journal-title":"Oncology Research"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.670299"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31824b4611"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-015-0171-1"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.02.036"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181cf3d79"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.02.035"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-017-0346-z"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.12.007"},{"issue":"5","key":"e_1_2_7_1_23_1","first-page":"7200","article-title":"Long non\u2010coding RNA LSINCT5 promotes ovarian cancer cell proliferation, migration and invasion by disrupting the CXCL12\/CXCR4 signalling axis","volume":"15","author":"Long X.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2017.69"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000518"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der395"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3143"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-0970-y"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051500"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.06.003"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.08.002"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-1816-1"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003"},{"issue":"18","key":"e_1_2_7_1_36_1","first-page":"3403","article-title":"Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR\u2010143","volume":"19","author":"Tuo Y. L.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_7_1_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.1926"},{"key":"e_1_2_7_1_38_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3640"},{"key":"e_1_2_7_1_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900413"},{"key":"e_1_2_7_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22645"}],"updated-by":[{"DOI":"10.1002\/jcp.30517","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"record-id":"31142"},{"DOI":"10.1002\/jcp.30517","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000}}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27163","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:27:39Z","timestamp":1747996059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/jcp.27163"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27163","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1002\/jcp.30517","asserted-by":"object"}]},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"assertion":[{"value":"2018-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}