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Cardiomyocytes hypertrophy is a compensatory form of heart disease characterized by increased size of cardiomyocytes. However, the link between cardiac hypertrophy and Se\u2010specific microRNA (miRNA) remains to be characterized. In the current study, we established a miR\u2010200a\u20105p mimic and an inhibitor cardiomyocytes model. Cardiomyocytes hypertrophy was induced in the miR\u2010200a\u20105p mimic group. Hence, we detected the glucose level of cardiomyocytes to estimate the cellular glucose uptake. The effect of miR\u2010200a\u20105p overexpression and the low expression on 25 selenoproteins mRNA levels was further explored using reverse transcription polymerase chain reaction. Overexpression of miR\u2010200a\u20105p elevated glucose uptake and Txnrd2, 3 expression and reduced Sepp1, Seln, Selt, and Sep15 expression in cardiomyocytes. Contrary results were observed in cardiomyocytes with the knockdown of miR\u2010200a\u20105p. We next assessed glucose metabolism\u2010related genes in cardiomyocytes. The results showed that miR\u2010200a\u20105p had a negative correlation with insulin\u2010like growth factor gene\u20101, insulin\u2010like growth factor binding protein (IGFBP)1, IGFBP2, IGFBP3, IGFBP4, and IGFBP5 and had a positive correlation with Akt, glucose transporter family (GLUT)2, GLUT3, and GLUT4. These results support the involvement of selenoproteins and glucose metabolism in the control of cardiomyocytes hypertrophy by Se\u2010specific miRNA, suggesting that miR\u2010200a\u20105p inhibited the expression of stress\u2010related selenoproteins to alter glucose transport leading to glucose metabolism disorder, eventually inducing cardiomyocytes hypertrophy. Our finding highlights a pivotal role of Se\u2010specific miRNA and selenoproteins in cardiac hypertrophy.<\/jats:p>","DOI":"10.1002\/jcp.27206","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T16:59:11Z","timestamp":1535216351000},"page":"4095-4103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["miR\u2010200a\u20105p augments cardiomyocyte hypertrophy induced by glucose metabolism disorder via the regulation of selenoproteins"],"prefix":"10.1002","volume":"234","author":[{"given":"Tianshu","family":"Yang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Foshan University, College of Life and Science Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3624-2410","authenticated-orcid":false,"given":"Shiwen","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Northeast Agricultural University Harbin China"},{"name":"Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province Northeast Agricultural University Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,25]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80595-4"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-0076-7"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-04-0322"},{"key":"e_1_2_8_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.1054"},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511386200"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00235a004"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-075820"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1485"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2011.05.007"},{"issue":"1","key":"e_1_2_8_1_12_1","first-page":"3","article-title":"Insulin\u2010like growth factors and their binding proteins: Biological actions","volume":"16","author":"Jones J. 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