{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:55:33Z","timestamp":1790258133594,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T00:00:00Z","timestamp":1539993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Marie Curie Career Reintegration","award":["PCIG09-GA-2011-293589"],"award-info":[{"award-number":["PCIG09-GA-2011-293589"]}]},{"name":"Excellence Departments, MIUR-Italy","award":["ARTICOLO 1"],"award-info":[{"award-number":["ARTICOLO 1"]}]},{"name":"Excellence Departments, MIUR-Italy","award":["COMMI 314-337 LEGGE 232\/2016"],"award-info":[{"award-number":["COMMI 314-337 LEGGE 232\/2016"]}]},{"name":"Excellence Departments, MIUR-Italy","award":["ARTICOLO 1"],"award-info":[{"award-number":["ARTICOLO 1"]}]},{"name":"PRIN 2015, MIUR -Italy","award":["2015SHM58M_004"],"award-info":[{"award-number":["2015SHM58M_004"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we investigated the protein network regulating cholesterol metabolism in the liver and brain of adolescent and adult male and female rats prenatally exposed to valproate (VPA), a well validated experimental model of autism spectrum disorders (ASD). We were aimed at studying whether prenatal VPA exposure affected the proteins involved in cholesterol homeostasis in a sex\u2010dependent manner. To this aim the protein network of cholesterol metabolism, in term of synthesis and plasma membrane trafficking, was analyzed by western blot in the liver and different brain areas (amygdala, cerebellum, cortex, hippocampus, nucleus accumbens, and dorsal striatum) of adolescent and adult male and female rats prenatally exposed to VPA. Our results show that physiological sex\u2010dependent differences are present both in the liver and in brain of rats. Interestingly, VPA affects specifically the brain in an age\u2010 and region\u2010specific manner; indeed, cerebellum, cortex, hippocampus and nucleus accumbens are affected in a sex\u2010dependent way, while this does not occur in amygdala and dorsal striatum. Overall, we demonstrate that each brain area responds differently to the same external stimulus and males and females respond in a different way, suggesting that this could be related to the diverse incidences, between the sexes, of some neurodevelopmental pathologies such as autism, which displays a 3:1 male to female ratio.<\/jats:p>","DOI":"10.1002\/jcp.27218","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T11:16:17Z","timestamp":1540034177000},"page":"4362-4374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prenatal exposure to valproate induces sex\u2010, age\u2010, and tissue\u2010dependent alterations of cholesterol metabolism: Potential implications on autism"],"prefix":"10.1002","volume":"234","author":[{"given":"Veronica","family":"Cartocci","sequence":"first","affiliation":[{"name":"Department of Science Section of Biomedical Sciences and Technologies, University \u201cRoma Tre,\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tonini","sequence":"additional","affiliation":[{"name":"Department of Science Section of Biomedical Sciences and Technologies, University \u201cRoma Tre,\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Di Pippo","sequence":"additional","affiliation":[{"name":"Department of Science Section of Biomedical Sciences and Technologies, University \u201cRoma Tre,\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florenzia","family":"Vuono","sequence":"additional","affiliation":[{"name":"Department of Science Section of Biomedical Sciences and Technologies, University \u201cRoma Tre,\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Department of Science Section of Biomedical 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