{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:25:00Z","timestamp":1792167900610,"version":"4.4.0"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["950909"],"award-info":[{"award-number":["950909"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colorectal cancer (CRC) is one of the most common cancers globally. Despite recent advances in therapeutic approaches, this cancer continues to have a poor prognosis, particularly when diagnosed late. 5\u2010Fluorouracil (5\u2010FU) has been commonly prescribed for patients with CRC, but resistance to 5\u2010FU is one of the main reasons for failure in the treatment of this condition. Recently, microRNAs (miRNAs) have been established as a means of modifying the signaling pathways involved in initiation and progression of CRC and their role as oncogene or tumor suppressor have been investigated in various studies. Moreover, miRNAs through various mechanisms play an important role in inducing tumor resistance or sensitivity to anticancer drugs. Detecting and targeting these mechanisms may be a new therapeutic approach. This review summarizes the current knowledge about the potential roles of miRNAs in 5\u2010FU resistance, with particular emphasis on molecular mechanism involved.<\/jats:p>","DOI":"10.1002\/jcp.27221","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T14:05:12Z","timestamp":1536329112000},"page":"2306-2316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["The role of microRNAs in 5\u2010FU resistance of colorectal cancer: Possible mechanisms"],"prefix":"10.1002","volume":"234","author":[{"given":"Reyhaneh Moradi","family":"Marjaneh","sequence":"first","affiliation":[{"name":"Torbat Heydarieh University of Medical Sciences Torbat Heydarieh Iran"},{"name":"Department of Medical Physiology Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-5699","authenticated-orcid":false,"given":"Majid","family":"Khazaei","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A.","family":"Ferns","sequence":"additional","affiliation":[{"name":"Department of Medical Education Brighton and Sussex Medical School  Perso Falmer Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-0962","authenticated-orcid":false,"given":"Amir","family":"Avan","sequence":"additional","affiliation":[{"name":"Department of Modern Sciences and Technologies Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Metabolic Syndrome Research Center, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-7837","authenticated-orcid":false,"given":"Seyed Hamid","family":"Aghaee\u2010Bakhtiari","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Department of Medical Biotechnology Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3057-3"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000169"},{"key":"e_1_2_5_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2010.10.006"},{"key":"e_1_2_5_1_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.07.740"},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.125"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.11.72"},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2817"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr214"},{"key":"e_1_2_5_1_10_1","first-page":"2015","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold M.","year":"2016","journal-title":"Gut"},{"key":"e_1_2_5_1_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/CBI20110089"},{"key":"e_1_2_5_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1361"},{"key":"e_1_2_5_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2014.09.008"},{"key":"e_1_2_5_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.11.064"},{"key":"e_1_2_5_1_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-016-0283-8"},{"key":"e_1_2_5_1_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2567-6"},{"key":"e_1_2_5_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2010.00220.x"},{"key":"e_1_2_5_1_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5259"},{"key":"e_1_2_5_1_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4810"},{"key":"e_1_2_5_1_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0583-1"},{"key":"e_1_2_5_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-014-0062-x"},{"key":"e_1_2_5_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.18"},{"key":"e_1_2_5_1_23_1","first-page":"1","article-title":"The effect of miR\u2010200c inhibition on chemosensitivity (5\u2010FluoroUracil) in colorectal cancer","author":"Heydari K.","year":"2017","journal-title":"Pathology & Oncology Research"},{"key":"e_1_2_5_1_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5278"},{"key":"e_1_2_5_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.09.025"},{"key":"e_1_2_5_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21888"},{"key":"e_1_2_5_1_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2015.3120"},{"key":"e_1_2_5_1_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.193"},{"key":"e_1_2_5_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2014.11.002"},{"key":"e_1_2_5_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-014-0528-9"},{"issue":"12","key":"e_1_2_5_1_31_1","first-page":"1484","article-title":"MicroRNA\u2010218 is a prognostic indicator in colorectal cancer and enhances 5\u2010fluorouracil\u2010induced apoptosis by targeting BIRC5","volume":"36","author":"Li P.\u2010L.","year":"2015","journal-title":"Carcinogenesis"},{"key":"e_1_2_5_1_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2014.3646"},{"key":"e_1_2_5_1_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920371604150429153309"},{"key":"e_1_2_5_1_34_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2726"},{"key":"e_1_2_5_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22710"},{"key":"e_1_2_5_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2016.04.011"},{"key":"e_1_2_5_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3152-5"},{"key":"e_1_2_5_1_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445653"},{"key":"e_1_2_5_1_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062880"},{"key":"e_1_2_5_1_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040958"},{"key":"e_1_2_5_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25801"},{"key":"e_1_2_5_1_42_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2246-1"},{"key":"e_1_2_5_1_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-13-0878"},{"key":"e_1_2_5_1_44_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.18-3-166"},{"key":"e_1_2_5_1_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134732"},{"key":"e_1_2_5_1_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.12.3461"},{"key":"e_1_2_5_1_47_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453311X13085644680140"},{"key":"e_1_2_5_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25897"},{"key":"e_1_2_5_1_49_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17971"},{"key":"e_1_2_5_1_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.06.032"},{"key":"e_1_2_5_1_51_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2016.1098619"},{"issue":"11","key":"e_1_2_5_1_52_1","first-page":"4605","article-title":"Overexpression of sialyltransferase CMP\u2010sialic acid: Gal\u03b21, 3GalNAc\u2010R \u03b16\u2010sialyltransferase is related to poor patient survival inhuman colorectal carcinomas","volume":"61","author":"Schneider F.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_5_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24721"},{"key":"e_1_2_5_1_54_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1202"},{"key":"e_1_2_5_1_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0178"},{"key":"e_1_2_5_1_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr153"},{"key":"e_1_2_5_1_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2015.01.020"},{"key":"e_1_2_5_1_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-015-1318-7"},{"key":"e_1_2_5_1_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00295"},{"key":"e_1_2_5_1_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015541107"},{"key":"e_1_2_5_1_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.11.039"},{"key":"e_1_2_5_1_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087451"},{"key":"e_1_2_5_1_63_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6545"},{"key":"e_1_2_5_1_64_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.015008"},{"issue":"5","key":"e_1_2_5_1_65_1","first-page":"620","article-title":"Drug resistance of colon cancer cells to 5\u2010fluorouracil mediated by microRNA\u201021","volume":"32","author":"Wu L.","year":"2015","journal-title":"Chinese Journal of Medical Genetics"},{"key":"e_1_2_5_1_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.05.006"},{"key":"e_1_2_5_1_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901451106"},{"key":"e_1_2_5_1_68_1","article-title":"CXCL12\/CXCR4 axis induced miR\u2010125b promotes invasion and confers 5\u2010fluorouracil resistance through enhancing autophagy in colorectal cancer","volume":"7","author":"Yu X.","year":"2017","journal-title":"Scientific Reports"},{"key":"e_1_2_5_1_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12485"},{"key":"e_1_2_5_1_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20215"},{"key":"e_1_2_5_1_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.10.029"},{"key":"e_1_2_5_1_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12742"},{"key":"e_1_2_5_1_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.200"},{"key":"e_1_2_5_1_74_1","article-title":"MiR\u201015b\u20105p resensitizes colon cancer cells to 5\u2010fluorouracil by promoting apoptosis via the NF\u2010\u03baB\/XIAP axis","volume":"7","author":"Zhao C.","year":"2017","journal-title":"Scientific Reports"},{"key":"e_1_2_5_1_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.60"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T05:05:18Z","timestamp":1744261518000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,7]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/jcp.27221"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27221","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,7]]},"assertion":[{"value":"2018-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}