{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:38:22Z","timestamp":1789403902531,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Synthetic corticosteroids are routinely administered during the treatment of several diseases, including malignancies. However, recent evidence suggests that corticosteroids may have tumor\u2010promoting effects, particularly in epithelial neoplasms. Our aim was to assess the role of the recently characterized cancer\u2010associated glucocorticoid (GC) system in the resistance to chemotherapy of oral malignant keratinocytes. Human malignant oral keratinocyte cell lines H314\/H357\/H400\/BICR16\/BICR56 were tested with: two chemotherapeutic agents, doxorubicin (DOXO) and 5\u2010fluorouracil (5\u2010FU), as well as hydrocortisone (HC), adrenocorticotropic hormone (ACTH), 5\u2010pregnen\u20103\u2010beta\u2010ol\u201020\u2010one\u201016\u2010alfa\u2010carbonitrile (PCN), and two glucose uptake inhibitors, Fasentin and WZB. Both DOXO and 5\u2010FU induced apoptosis in a dose\u2010dependent and time\u2010dependent manner. HC administration (100\u2009nM) reduced the effectiveness of both chemotherapeutic agents to a variable extent in all 5 oral squamous cell carcinoma cell lines. ACTH also reduced the effectiveness of DOXO on 2 cell lines tested (H357 and BICR56). The glucose uptake inhibitors Fasentin and WZB were able to partially block the increased resistance to the cytotoxic drugs induced by HC. In summary, we have demonstrated, for the first time, the importance of cortisol on oral cancer cells ability to proliferate and combat the effectiveness of chemotherapeutic agents. This effect appears to be glucose dependent.<\/jats:p>","DOI":"10.1002\/jcp.27227","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:52:11Z","timestamp":1537581131000},"page":"2013-2020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Glucocorticoids reduce chemotherapeutic effectiveness on OSCC cells via glucose\u2010dependent mechanisms"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-2511","authenticated-orcid":false,"given":"Antonio","family":"Celentano","sequence":"first","affiliation":[{"name":"Melbourne Dental School The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McCullough","sequence":"additional","affiliation":[{"name":"Melbourne Dental School The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-1323","authenticated-orcid":false,"given":"Nicola","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Melbourne Dental School The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.24.10705"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25408"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6349"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053422"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511427909"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.243"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23081"},{"issue":"3","key":"e_1_2_7_1_9_1","first-page":"279","article-title":"Main molecular markers of oral squamous cell carcinoma","volume":"30","author":"Daniel F. 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