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The TRPM2 ion channel is expressed in the kidney and can be activated by various molecules such as hydrogen peroxide, calcium, and cyclic adenosine diphosphate (ADP)\u2010ribose (cADPR) that are produced during acute kidney injury. In this study, we investigated the role of 8\u2010bromo\u2010cyclic ADP\u2010ribose (8\u2010Br\u2010cADPR; a cADPR antagonist) in renal ischemia\u2013reperfusion injury using biochemical and histopathological parameters. CD38, cADPR, tumor necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, and myeloperoxidase (inflammatory markers), urea and creatinine, hydrogen peroxide (oxidant), and catalase (antioxidant enzyme) levels that increase with ischemia\u2013reperfusion injury decreased in the groups treated with 8\u2010Br\u2010cADPR. In addition, renin levels were elevated in the groups treated with 8\u2010Br\u2010cADPR. Histopathological examination revealed that 8\u2010Br\u2010cADPR reduced renal damage and the expression of caspase\u20103 and TRPM2. Our results suggest that the inhibition of TRPM2 ion channel may be a new treatment modality for ischemic acute kidney injury.<\/jats:p>","DOI":"10.1002\/jcp.27236","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T11:01:22Z","timestamp":1536318082000},"page":"4572-4581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["8\u2010Br\u2010cADPR,\u00a0a TRPM2 ion channel antagonist, inhibits renal ischemia\u2013reperfusion injury"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2424-2269","authenticated-orcid":false,"given":"Ersen","family":"Eraslan","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine, University of Bozok Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayhan","family":"Tanyeli","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine, University of Atat\u00fcrk Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine, University of Atat\u00fcrk Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Faculty of Medicine, University of Nam\u0131k Kemal Tekirda\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,7]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1439-x"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.455"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9835-0"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0774"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.3.C741"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113498"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.163"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506462"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10520295.2017.1283056"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.03.022"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00217.2006"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065000"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003367"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)47970-7"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0450fje"},{"issue":"2","key":"e_1_2_9_1_17_1","first-page":"R922","article-title":"Early kidney TNF\u2010alpha expression mediates neutrophil infiltration and injury after renal ischemia\u2010reperfusion","volume":"277","author":"Donnahoo K. 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