{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:44:49Z","timestamp":1780638289348,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270192"],"award-info":[{"award-number":["81270192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to explore long noncoding RNAs (lncRNAs) implicated in dilated cardiomyopathy (DCM). Ten samples of failing hearts collected from the left ventricles of patients with\u00a0DCM undergoing heart transplants, and ten control samples obtained from normal heart donors were included in this study. After sequencing, differentially expressed genes (DEGs) and lncRNAs between DCM and controls were screened, followed with functional enrichment analysis and weighted gene coexpression network analysis (WGCNA). Five key lncNRAs were validated through real\u2010time polymerase chain reaction (PCR). Total 1,398 DEGs were identified, including 267 lncRNAs. WGCNA identified seven modules that were significantly correlated with DCM. The top 50 genes in the three modules (black, dark\u2010green, and green\u2013yellow) were significantly correlated with DCM disease state. Four core enrichment lncRNAs, such as AC061961.2, LING01\u2010AS1, and RP11\u2013557H15.4, in the green\u2013yellow module were associated with neurotransmitter secretion. Five core enrichment lncRNAs, such as KB\u20101299A7.2 and RP11\u201313E1.5, in the black module were associated with the functions of blood circulation and heart contraction. AC061961.2, LING01\u2010AS1, and RP11\u201313E1.5 were confirmed to be downregulated in DCM tissues by real\u2010time PCR. The current study suggests that downregulation of AC061961.2, LING01\u2010AS1, and RP11\u201313E1.5 may be associated with DCM progression, which may serve as key diagnostic biomarkers and therapeutic targets for DCM.<\/jats:p>","DOI":"10.1002\/jcp.27247","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T06:40:26Z","timestamp":1536648026000},"page":"4460-4471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Downregulation of AC061961.2, LING01\u2010AS1, and RP11\u201313E1.5 is associated with dilated cardiomyopathy progression"],"prefix":"10.1002","volume":"234","author":[{"given":"Zhibing","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Nanjing First Hospital, Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Yangzhou Maternal and Child Health Hospital Yangzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Nanjing First Hospital, Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Nanjing First Hospital, Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Nanjing First Hospital, Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-3376","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Nanjing First Hospital, Nanjing Medical University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00380-4"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-2"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2006.06.009"},{"key":"e_1_2_7_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.12.014"},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.1.e2"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_2_7_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004133421502"},{"key":"e_1_2_7_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw095"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.6.1363"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-016-0926-5"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.135350.111"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62023-7"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells3030883"},{"issue":"1","key":"e_1_2_7_1_15_1","first-page":"10","article-title":"Fibrosis in heart disease: Understanding the role of transforming growth factor\u2010beta in cardiomyopathy, valvular disease and arrhythmia","volume":"118","author":"Khan R.","year":"2010","journal-title":"Insect Science"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/16.suppl_O.100"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303915"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2012.01.013"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132939"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-2-200507190-00009"},{"issue":"1","key":"e_1_2_7_1_22_1","first-page":"108","article-title":"In vivo assessment of neurotransmitter system in cardiovascular diseases. Clinical issues","volume":"40","author":"Merlet P.","year":"1996","journal-title":"The Quarterly Journal of Nuclear Medicine"},{"key":"e_1_2_7_1_23_1","first-page":"303265","article-title":"The long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth","volume":"113","author":"Michalik K. M.","year":"2014","journal-title":"Circulation Research"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu180"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3122"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13339"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00319.2001"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.6.701"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr026"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.0981"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.093869"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1003"},{"key":"e_1_2_7_1_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303549"},{"key":"e_1_2_7_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(95)80236-F"},{"key":"e_1_2_7_1_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp120"},{"key":"e_1_2_7_1_38_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.124370.111"},{"key":"e_1_2_7_1_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.110833"},{"key":"e_1_2_7_1_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_7_1_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15544"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T12:29:05Z","timestamp":1748003345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/jcp.27247"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27247","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"2018-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}