{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:00Z","timestamp":1791919500806,"version":"4.3.4"},"reference-count":194,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Melanoma is known as an aggressive tumor which shows an increasing incidence and poor prognosis in the metastatic phase. Hence, it seems that diagnosis and effective management (including early diagnosis, choosing of the effective therapeutic platform, caring, and training of patients for early detection) are major aspects of melanoma therapy. Early detection of melanoma is a key point for melanoma therapy. There are various diagnosis options such as assessing of biopsy, imaging techniques, and biomarkers (i.e., several proteins, polymorphism, and liquid biopsy). Among the various biomarkers, assessing circulating tumor cells, cell\u2010free DNAs, cell\u2010free RNAs, and microRNAs (miRNAs) have emerged as powerful diagnosis tools for melanoma patients. Deregulations of these molecules are associated with melanoma pathogenesis. After detection of melanoma, choosing of effective therapeutic regimen is a key step for recovery of melanoma patients. Several studies indicated that various therapeutic approaches including surgery, immunotherapy, systematic therapy, radiation therapy and antibodies therapy could be used as potential therapeutic candidates for melanoma therapy. Caring for melanoma patients is one of the important components of melanoma therapy. Caring and training for melanoma patients could contribute to better monitoring of patients in response to various therapeutic options. Here, we summarized various diagnosis approaches such as assessing biopsy, imaging techniques, and utilization of various biomarkers (i.e., proteins, CTCs, cfDNAs, and miRNAs) as a diagnostic biomarker for detection and monitoring patients with melanoma. Moreover, we highlighted various therapeutic options and caring aspects in patients with melanoma.<\/jats:p>","DOI":"10.1002\/jcp.27286","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T10:39:24Z","timestamp":1540550364000},"page":"3307-3320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Melanoma: Where we are and where we go"],"prefix":"10.1002","volume":"234","author":[{"given":"Ali","family":"Mohammadpour","sequence":"first","affiliation":[{"name":"Faculty of Nursing and Midwifery Gonabad University of Medical Sciences Gonabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Derakhshan","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Isfahan Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Darabi","sequence":"additional","affiliation":[{"name":"Medical Genetics Research Center, Department of Medical Genetics Faculty of Medicine, Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Hedayat","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Isfahan Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-5775","authenticated-orcid":false,"given":"Mohammad","family":"Momeni","sequence":"additional","affiliation":[{"name":"Department of Radiology Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"e_1_2_7_1_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.11.044"},{"key":"e_1_2_7_1_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20010185"},{"key":"e_1_2_7_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.12.031"},{"key":"e_1_2_7_1_5_1","unstructured":"American Cancer SocietyCancer Facts & Figures 2012.2012."},{"key":"e_1_2_7_1_6_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.622"},{"key":"e_1_2_7_1_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.5448"},{"issue":"10","key":"e_1_2_7_1_8_1","article-title":"Diet and cancer prevention: Dietary compounds, dietary micrornas and dietary exosomes","volume":"28","author":"Banikazemi Z.","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"issue":"23","key":"e_1_2_7_1_9_1","first-page":"5475","article-title":"The p16\u2010cyclin D\/Cdk4\u2010pRb pathway as a functional unit frequently altered in melanoma pathogenesis","volume":"56","author":"Bartkova J.","year":"1996","journal-title":"Cancer Research"},{"key":"e_1_2_7_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.iio.0000195852.08453.de"},{"key":"e_1_2_7_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08822"},{"key":"e_1_2_7_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.324"},{"key":"e_1_2_7_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35020115"},{"key":"e_1_2_7_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-380890-5.00003-X"},{"key":"e_1_2_7_1_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.746"},{"key":"e_1_2_7_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_2_7_1_17_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.091061"},{"key":"e_1_2_7_1_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S45429"},{"key":"e_1_2_7_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5915"},{"key":"e_1_2_7_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki200"},{"key":"e_1_2_7_1_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-197"},{"key":"e_1_2_7_1_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-197"},{"key":"e_1_2_7_1_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq033"},{"key":"e_1_2_7_1_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.1.35"},{"key":"e_1_2_7_1_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2516"},{"key":"e_1_2_7_1_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050092"},{"key":"e_1_2_7_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207780"},{"key":"e_1_2_7_1_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt003"},{"key":"e_1_2_7_1_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.227611"},{"key":"e_1_2_7_1_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_7_1_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.00.240"},{"key":"e_1_2_7_1_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0b013e3282f75eb1"},{"key":"e_1_2_7_1_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194546"},{"key":"e_1_2_7_1_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.044"},{"issue":"2","key":"e_1_2_7_1_35_1","first-page":"171","article-title":"Phase II trial of carboplatin in advanced malignant melanoma","volume":"71","author":"Evans L. M.","year":"1987","journal-title":"Cancer Treatment Reports"},{"key":"e_1_2_7_1_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04750.x"},{"key":"e_1_2_7_1_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800731200"},{"key":"e_1_2_7_1_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.052779"},{"key":"e_1_2_7_1_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.34"},{"key":"e_1_2_7_1_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2538"},{"key":"e_1_2_7_1_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056824"},{"key":"e_1_2_7_1_42_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.157.2.4048453"},{"key":"e_1_2_7_1_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3218"},{"key":"e_1_2_7_1_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"e_1_2_7_1_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1203421"},{"key":"e_1_2_7_1_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317701646"},{"key":"e_1_2_7_1_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-155"},{"issue":"155","key":"e_1_2_7_1_48_1","first-page":"1479","article-title":"Serum microRNAs as biomarkers for recurrence in melanoma","volume":"10","author":"Friedman E. B.","year":"2012","journal-title":"Journal of Translational Medicine"},{"key":"e_1_2_7_1_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0157"},{"key":"e_1_2_7_1_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03184.x"},{"key":"e_1_2_7_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.03.034"},{"key":"e_1_2_7_1_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.10.014"},{"key":"e_1_2_7_1_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03664"},{"key":"e_1_2_7_1_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-005-1264-9"},{"key":"e_1_2_7_1_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.05.027"},{"key":"e_1_2_7_1_56_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824b1efd"},{"issue":"10","key":"e_1_2_7_1_57_1","first-page":"25793","article-title":"GD2\u2010targeted immunotherapy and potential value of circulating microRNAs in neuroblastoma","volume":"1","author":"Gholamin S.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_7_1_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cji.0000211343.73588.59"},{"key":"e_1_2_7_1_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904293401707"},{"key":"e_1_2_7_1_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000249888.41884.6c"},{"key":"e_1_2_7_1_61_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.4.574"},{"issue":"10","key":"e_1_2_7_1_62_1","article-title":"MicroRNAs in retinoblastoma: Potential diagnostic and therapeutic biomarkers","volume":"28","author":"Golabchi K.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"issue":"23","key":"e_1_2_7_1_63_1","first-page":"5336","article-title":"Low frequency of p16\/CDKN2A methylation in sporadic melanoma: Comparative approaches for methylation analysis of primary tumors","volume":"57","author":"Gonzalgo M. L.","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_7_1_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1722"},{"key":"e_1_2_7_1_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11376"},{"issue":"17","key":"e_1_2_7_1_66_1","first-page":"3660","article-title":"Disruption of the MMAC1\/PTEN gene by deletion or mutation is a frequent event in malignant melanoma","volume":"57","author":"Guldberg P.","year":"1997","journal-title":"Cancer Research"},{"key":"e_1_2_7_1_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011574"},{"key":"e_1_2_7_1_68_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305133"},{"key":"e_1_2_7_1_69_1","doi-asserted-by":"publisher","DOI":"10.5732\/cjc.014.10118"},{"issue":"10","key":"e_1_2_7_1_70_1","article-title":"Nanoparticles as new tools for inhibition of cancer angiogenesis","volume":"25","author":"Hashemi Goradel N.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"issue":"5","key":"e_1_2_7_1_71_1","first-page":"1065","article-title":"PAX4 has the potential to function as a tumor suppressor in human melanoma","volume":"33","author":"Hata S.","year":"2008","journal-title":"International Journal of Oncology"},{"key":"e_1_2_7_1_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206445"},{"key":"e_1_2_7_1_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-017-0039-5"},{"key":"e_1_2_7_1_74_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.0707"},{"key":"e_1_2_7_1_75_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"e_1_2_7_1_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01720.x"},{"key":"e_1_2_7_1_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199805000-00017"},{"key":"e_1_2_7_1_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-006-8500-x"},{"key":"e_1_2_7_1_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207505"},{"issue":"10","key":"e_1_2_7_1_80_1","article-title":"NLRP3 inflammasome: Its regulation and involvement in atherosclerosis","volume":"27","author":"Hoseini Z.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_7_1_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.12.008"},{"key":"e_1_2_7_1_82_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.5.17.3133"},{"key":"e_1_2_7_1_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.12.152"},{"key":"e_1_2_7_1_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26850"},{"key":"e_1_2_7_1_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.82"},{"key":"e_1_2_7_1_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21791"},{"key":"e_1_2_7_1_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.004"},{"key":"e_1_2_7_1_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210252"},{"key":"e_1_2_7_1_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.03.008"},{"key":"e_1_2_7_1_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8153634"},{"issue":"8","key":"e_1_2_7_1_91_1","first-page":"740","article-title":"Tyrosinase, melan\u2010A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections","volume":"11","author":"Kaufmann O.","year":"1998","journal-title":"Modern Pathology"},{"issue":"2","key":"e_1_2_7_1_92_1","first-page":"81","article-title":"Tumor follow\u2010up using sonography and computed tomography in the abdominal region of patients with malignant melanoma","volume":"2","author":"Kaufmann P. M.","year":"1992","journal-title":"Aktuelle Radiologie"},{"key":"e_1_2_7_1_93_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2017-0170"},{"key":"e_1_2_7_1_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26042"},{"issue":"10","key":"e_1_2_7_1_95_1","article-title":"Oral tumors in children: Diagnosis and management","volume":"3","author":"Khanmohammadi R.","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"key":"e_1_2_7_1_96_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909409038234"},{"key":"e_1_2_7_1_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.468"},{"key":"e_1_2_7_1_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65172-3"},{"key":"e_1_2_7_1_99_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.7"},{"key":"e_1_2_7_1_100_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3172"},{"issue":"13","key":"e_1_2_7_1_101_1","first-page":"3724","article-title":"Allele loss and promoter hypermethylation of VHL, RAR\u2010\u03b2, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma","volume":"63","author":"Kuroki T.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_7_1_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-1892-6"},{"key":"e_1_2_7_1_103_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-262"},{"key":"e_1_2_7_1_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.11.020"},{"key":"e_1_2_7_1_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21372"},{"key":"e_1_2_7_1_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0757-5"},{"key":"e_1_2_7_1_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2964"},{"key":"e_1_2_7_1_108_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.16.6533"},{"key":"e_1_2_7_1_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.06.004"},{"issue":"10","key":"e_1_2_7_1_110_1","article-title":"Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis","volume":"13","author":"Mashreghi M.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"issue":"10","key":"e_1_2_7_1_111_1","article-title":"MiR\u201021: A key player in glioblastoma pathogenesis","volume":"20","author":"Masoudi M. S.","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"key":"e_1_2_7_1_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00881.x"},{"key":"e_1_2_7_1_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.02.020"},{"key":"e_1_2_7_1_114_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.30909.x"},{"key":"e_1_2_7_1_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(03)00006-6"},{"key":"e_1_2_7_1_116_1","doi-asserted-by":"publisher","DOI":"10.1188\/08.CJON.307-313"},{"key":"e_1_2_7_1_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052166"},{"issue":"10","key":"e_1_2_7_1_118_1","article-title":"Stroke in women: Risk factors and clinical biomarkers","volume":"12","author":"Mirzaei H.","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"issue":"10","key":"e_1_2_7_1_119_1","first-page":"25799","article-title":"State of the art in microRNA as diagnostic and therapeutic biomarkers in chronic lymphocytic leukemia","volume":"13","author":"Mirzaei H.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_7_1_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2017.06.004"},{"key":"e_1_2_7_1_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.10.009"},{"key":"e_1_2_7_1_122_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160818093854"},{"issue":"10","key":"e_1_2_7_1_123_1","article-title":"MicroRNA: A novel target of curcumin in cancer therapy","volume":"15","author":"Mirzaei H.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"issue":"10","key":"e_1_2_7_1_124_1","first-page":"25787","article-title":"MicroRNA: Relevance to stroke diagnosis, prognosis, and therapy","volume":"9","author":"Mirzaei H.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_7_1_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30224"},{"key":"e_1_2_7_1_126_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666151217122033"},{"key":"e_1_2_7_1_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25739"},{"key":"e_1_2_7_1_128_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666160303110838"},{"key":"e_1_2_7_1_129_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.153661"},{"key":"e_1_2_7_1_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701072"},{"key":"e_1_2_7_1_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.45"},{"key":"e_1_2_7_1_132_1","unstructured":"Mohammadpour A. The most common skin side effect of systematic chemotherapy and radio therapy: Prevention & care in patients with cancer. 18th International Annual Meeting of the Cancer Institute of Iran TUMS October2007."},{"issue":"10","key":"e_1_2_7_1_133_1","first-page":"25801","article-title":"MicroRNAs: Potential candidates for diagnosis and treatment of colorectal cancer","volume":"16","author":"Moridikia A.","year":"2017","journal-title":"Journal of Cellular Physiology"},{"key":"e_1_2_7_1_134_1","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v8n4p102"},{"key":"e_1_2_7_1_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1983.tb01489.x"},{"key":"e_1_2_7_1_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0398-328"},{"key":"e_1_2_7_1_137_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.3.14056"},{"key":"e_1_2_7_1_138_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.325027"},{"key":"e_1_2_7_1_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-7357-2_30"},{"key":"e_1_2_7_1_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.1270"},{"key":"e_1_2_7_1_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.10.028"},{"key":"e_1_2_7_1_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2014.07.012"},{"key":"e_1_2_7_1_143_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NME.0000390926.78677.c4"},{"key":"e_1_2_7_1_144_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.4.316"},{"issue":"10","key":"e_1_2_7_1_145_1","first-page":"26146","article-title":"Plasminogen activator inhibitor Type\u20101 as a regulator of fibrosis","volume":"18","author":"Rabieian R.","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"key":"e_1_2_7_1_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25738"},{"key":"e_1_2_7_1_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.161"},{"key":"e_1_2_7_1_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.400"},{"key":"e_1_2_7_1_149_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03400210088032"},{"key":"e_1_2_7_1_150_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104621"},{"key":"e_1_2_7_1_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077246"},{"key":"e_1_2_7_1_152_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198812223192527"},{"key":"e_1_2_7_1_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2355"},{"key":"e_1_2_7_1_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.48"},{"issue":"10","key":"e_1_2_7_1_155_1","first-page":"62","article-title":"Molecular imaging and cancer gene therapy","volume":"18","author":"Saadatpour Z.","year":"2016","journal-title":"Cancer Gene Therapy"},{"issue":"10","key":"e_1_2_7_1_156_1","article-title":"Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome","volume":"8","author":"Saeedi Borujeni M. J.","year":"2017","journal-title":"Journal of Cellular Biochemistry"},{"issue":"3","key":"e_1_2_7_1_157_1","first-page":"205","article-title":"corelation between uncertainty in illneess, demographic and clinical factors with adherence to treatment in patients with cancer","volume":"24","author":"Sajadi M.","year":"2017","journal-title":"Journal of Sabzevar University of Medical Sciences"},{"key":"e_1_2_7_1_158_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2345"},{"key":"e_1_2_7_1_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24960"},{"issue":"11","key":"e_1_2_7_1_160_1","first-page":"3200","article-title":"Cyclin D1 is a candidate oncogene in cutaneous melanoma","volume":"62","author":"Sauter E. R.","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_7_1_161_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2015.03.006"},{"key":"e_1_2_7_1_162_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2721"},{"key":"e_1_2_7_1_163_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808263106"},{"key":"e_1_2_7_1_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206461"},{"issue":"1","key":"e_1_2_7_1_165_1","first-page":"15","article-title":"Expression of microRNA\u2010100 in human gastric cancer","volume":"42","author":"Shi D. B.","year":"2013","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"e_1_2_7_1_166_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_1_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/35051606"},{"issue":"7","key":"e_1_2_7_1_168_1","first-page":"1639","article-title":"Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma","volume":"63","author":"Spugnardi M.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_7_1_169_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1399"},{"key":"e_1_2_7_1_170_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4152"},{"key":"e_1_2_7_1_171_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.195.3.7753998"},{"key":"e_1_2_7_1_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19971021)74:5<535::AID-IJC10>3.0.CO;2-5"},{"key":"e_1_2_7_1_173_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3182a3877a"},{"key":"e_1_2_7_1_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.263"},{"key":"e_1_2_7_1_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00025-6"},{"key":"e_1_2_7_1_176_1","doi-asserted-by":"publisher","DOI":"10.1308\/003588408X285856"},{"key":"e_1_2_7_1_177_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e32832b274e"},{"issue":"1","key":"e_1_2_7_1_178_1","first-page":"764","article-title":"CpG island hypermethylation profile of human melanoma cell lines in relation to global methylation and mutations in BRAF and NRAS","volume":"2006","author":"Tellez C. S.","year":"2006","journal-title":"Proceedings of the American Association for Cancer Research"},{"key":"e_1_2_7_1_179_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9941"},{"key":"e_1_2_7_1_180_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0105"},{"key":"e_1_2_7_1_181_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030000186"},{"key":"e_1_2_7_1_182_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202X.2004.22243.x"},{"key":"e_1_2_7_1_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10605"},{"key":"e_1_2_7_1_184_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.30.143"},{"key":"e_1_2_7_1_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.10.029"},{"key":"e_1_2_7_1_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1154"},{"key":"e_1_2_7_1_187_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2451"},{"key":"e_1_2_7_1_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4326"},{"issue":"6","key":"e_1_2_7_1_189_1","first-page":"13","article-title":"Diagnostic and prognostic biomarkers in melanoma","volume":"7","author":"Weinstein D.","year":"2014","journal-title":"The Journal of Clinical and Aesthetic Dermatology"},{"key":"e_1_2_7_1_190_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206451"},{"key":"e_1_2_7_1_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.568"},{"key":"e_1_2_7_1_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23931.x"},{"key":"e_1_2_7_1_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20303"},{"issue":"10","key":"e_1_2_7_1_194_1","first-page":"1472","article-title":"Oncology patients\u2019 and professional nurses\u2019 perceptions of important nurse caring behaviors","volume":"9","author":"Zamanzadeh V.","year":"2010","journal-title":"BMC Nursing"},{"issue":"6","key":"e_1_2_7_1_195_1","first-page":"392","article-title":"Target prediction and verification of miR\u201027a in pancreatic cancer","volume":"42","author":"Zhang T. T.","year":"2013","journal-title":"Zhonghua Bing Li Xue Za Zhi"}],"container-title":["Journal of Cellular Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcp.27286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcp.27286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcp.27286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:28:04Z","timestamp":1747996084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcp.27286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":194,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1002\/jcp.27286"],"URL":"https:\/\/doi.org\/10.1002\/jcp.27286","archive":["Portico"],"relation":{},"ISSN":["0021-9541","1097-4652"],"issn-type":[{"value":"0021-9541","type":"print"},{"value":"1097-4652","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]},"assertion":[{"value":"2018-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}