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It was reported that Sirt3 got involved in the alleviation of multiple diseases, including myocardial infarction, neuron ischemia, hypertrophy, and diabetic myopathy. Through regulating many cellular mechanisms, such as apoptosis, autophagy, and clearance of reactive oxygen species (ROS), Sirt3 played an important role in the alleviation of myocardial ischemia\u2013reperfusion injury. Nowadays Sirt3\u2010induced autophagy was indicated to be involved in the process of the development of myocardial ischemia\u2013reperfusion injury. Sirt3 could both activate and inhibit autophagy process by activating different downstream signal pathways, such as Sirt3\u2013AMP\u2010activated protein kinase pathway, Sirt3\u2013Foxo3a pathway, and Sirt3\u2013superoxide dismutase\u2013mitochondrial ROS pathway. Whereas the Sirt3\u2010induced autophagy in different phases of myocardial ischemia\u2013reperfusion has not been systematically illustrated. In this review, we summarized the regulated mechanisms found in these years and listed the updated research about the relationship between Sirt3 and autophagy which are both positive and negative during myocardial ischemia\u2013reperfusion phase. We anticipated that we may controlled the activation of autophagy by regulating the concentration of Sirt3 in myocyte. By maintaining a proper expression of autophagy in different phases of myocardial ischemia\u2013reperfusion, we could reduce the morbidity of patients with myocardial infarction apparently in the future.<\/jats:p>","DOI":"10.1002\/jcp.27329","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T18:08:11Z","timestamp":1543428491000},"page":"5488-5495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["The novel relationship between Sirt3 and autophagy in myocardial ischemia\u2013reperfusion"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4438-845X","authenticated-orcid":false,"given":"Yitian","family":"Zheng","sequence":"first","affiliation":[{"name":"Cardiology Department, The First Affiliated Hospital of Anhui Medical University Hefei City, Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhao","family":"Shi","sequence":"additional","affiliation":[{"name":"Cardiology Department, The First Affiliated Hospital of Anhui Medical University Hefei City, Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqing","family":"Ma","sequence":"additional","affiliation":[{"name":"Cardiology Department, The First Affiliated Hospital of Anhui Medical University Hefei City, Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Wu","sequence":"additional","affiliation":[{"name":"Cardiology Department, The First Affiliated Hospital of Anhui Medical University Hefei City, Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhe","family":"Lin","sequence":"additional","affiliation":[{"name":"Cardiology Department, The First Affiliated Hospital of Anhui Medical University Hefei City, Anhui Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00213-8"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2270"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.5.1886-1896.2000"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600254"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.7.8.15813"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.04.005"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.03.001"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/345105"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1074248410370327"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.3.12106"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08197"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100831"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.187427"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2523"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-4924-2-28"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.8"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12453"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3293"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12211"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.01.004"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0626-1"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25865"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.06.026"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"crossref","unstructured":"Lambert A. 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