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Heme oxygenase\u20101 (HO\u20101) is a key enzyme of antioxidative metabolism in association with cell resistance to apoptosis. Our previous studies have shown that overexpression of HO\u20101 resulted in resistance development to IM in CML cells, while the mechanism remains unclear. In the current study, the IM\u2010resistant CML cells K562R indicated upregulation of some of the histone deacetylases (HDACs) compared with K562 cells. Therefore, we herein postulated HO\u20101 was associated with HDACs. Silencing HO\u20101 expression in K562R cells inhibited the expression of some HDACs, and the sensitivity to IM was increased. K562 cells transfected with HO\u20101 resisted IM and underwent obvious some HDACs. These findings related to the inhibitory effects of high HO\u20101 expression on the reactive oxygen species (ROS) signaling pathway that negatively regulated HDACs. Increased expression of HO\u20101 activated HDACs by inhibiting ROS production. In summary, HO\u20101, which is involved in the development of drug resistance in CML cells by regulating the expression of HDACs, is probably a novel target for improving CML therapy.<\/jats:p>","DOI":"10.1002\/jcp.27334","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T09:40:06Z","timestamp":1536313206000},"page":"5252-5263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Heme oxygenase\u20101 reduces the sensitivity to imatinib through nonselective activation of histone deacetylases in chronic myeloid leukemia"],"prefix":"10.1002","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0966-1289","authenticated-orcid":false,"given":"Danna","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Guizhou Medical University Guiyang PR China"},{"name":"Department of Key Laboratory of Hematological Disease Diagnostic and 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