{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T19:16:08Z","timestamp":1782414968650,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Cellular Physiology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurotrophic keratopathy (NK) is a rare degenerative corneal disorder characterized by instability of epithelial integrity with consequent epithelial defects that can worsen up to persistent epithelial defects with stromal melting and ulceration. The pathogenesis of NK springs from a variable degree of damage to the trigeminal nerve plexus, leading to a reduction or total loss of corneal sensitivity. Mackie classification (1995) distinguishes three stages of NK, based on the severity of clinical presentation. The technological innovations in corneal diagnostic imaging allow clinicians to accurately study the morphometry and morphology of corneal structure with microscopic resolution. In this study, 45 patients affected by NK at different stages underwent in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS\u2010OCT) with particular attention to analyze subbasal nerve plexus fibers and the stromal structure. At the light of IVCM and AS\u2010OCT observations, we propose a different staging of NK with respect to the Mackie's classification that takes into account the severity of subbasal nerve fibers damage and the extension in depth of stromal ulceration; this classification better defines, at the time of diagnosis, the cellular and structural alterations in the affected corneas, with possible prognostic and therapeutic values in the management of NK.<\/jats:p>","DOI":"10.1002\/jcp.27345","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T01:55:51Z","timestamp":1537581351000},"page":"6108-6115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["In vivo microscopic and optical coherence tomography classification of neurotrophic keratopathy"],"prefix":"10.1002","volume":"234","author":[{"given":"Leonardo","family":"Mastropasqua","sequence":"first","affiliation":[{"name":"Department of Medicine and Science of Ageing Ophthalmic Clinic, National High Technology Eye Center, G. d\u2019Annunzio University of Chieti Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Nubile","sequence":"additional","affiliation":[{"name":"Department of Medicine and Science of Ageing Ophthalmic Clinic, National High Technology Eye Center, G. d\u2019Annunzio University of Chieti Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2615-1408","authenticated-orcid":false,"given":"Manuela","family":"Lanzini","sequence":"additional","affiliation":[{"name":"Department of Medicine and Science of Ageing Ophthalmic Clinic, National High Technology Eye Center, G. d\u2019Annunzio University of Chieti Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Calienno","sequence":"additional","affiliation":[{"name":"Department of Medicine and Science of Ageing Ophthalmic Clinic, National High Technology Eye Center, G. d\u2019Annunzio University of Chieti Pescara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harminder S.","family":"Dua","sequence":"additional","affiliation":[{"name":"Division of Clinical Neuroscience, Department of Ophthalmology Section of Academic Ophthalmology, University of Nottingham Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_5_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.173799"},{"key":"e_1_2_5_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.002"},{"key":"e_1_2_5_1_4_1","article-title":"Phase I trial of recombinant human nerve growth factor for neurotrophic keratitis","author":"Bonini S.","year":"2018","journal-title":"Opthamology"},{"key":"e_1_2_5_1_5_1","article-title":"Phase 2 randomized, double\u2010masked, vehicle\u2010controlled trial of recombinant human nerve growth factor for neurotrophic keratitis","author":"Bonini S.","year":"2018","journal-title":"Opthamology."},{"key":"e_1_2_5_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21377"},{"key":"e_1_2_5_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2016.09.004."},{"key":"e_1_2_5_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.06.010"},{"key":"e_1_2_5_1_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303890"},{"key":"e_1_2_5_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12697"},{"key":"e_1_2_5_1_11_1","first-page":"S1350","article-title":"Neurotrophic keratopathy","volume":"23","author":"Dua H. 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